Kealy W F, Annis P G, Barry J A, Hogan J M
Department of Histopathology, Regional Hospital, Wilton, Cork, Ireland.
J Clin Pathol. 1990 Jul;43(7):554-9. doi: 10.1136/jcp.43.7.554.
The observation of koilocyte-like features in the squamous epithelium of some endometrial adenoacanthomas prompted an investigation into a possible viral aetiology. These changes closely resemble those that occur in the ectocervical mucosa which are accepted as morphological evidence of human papillomavirus (HPV) infection. Sections of 87 hysterectomy specimens removed for endometrial carcinoma over 12 years, together with preoperative curettings, were reviewed for the presence of acanthomatous change and for appearances suggestive of HPV infection. The ages of the women ranged from 36 to 84 years, average age 62.6. Light microscopical examination showed koilocytosis, papillary formations, and intranuclear eosinophilic inclusions of both squamous and glandular epithelium in some tumours. Immunocytochemistry and DNA in situ hybridisation indicated the presence of HPV antigen in squamous and glandular cells, and perinuclear virus particles characteristic of HPV were seen on electron microscopical examination in those cells with nuclear inclusions. HPV probably infects endometrial adenocarcinomas directly from the cervix but it is unlikely that it has an aetiological role. It is possible, however, that in addition to being a "passenger," the virus may stimulate squamous metaplasia in some adenocarcinomas of the endometrium and may also exert some influence on their behaviour.
在一些子宫内膜腺棘皮瘤的鳞状上皮中观察到核周空泡化细胞样特征，促使人们对可能的病毒病因进行调查。这些变化与发生在外宫颈黏膜中的变化非常相似，而外宫颈黏膜中的这些变化被认为是人乳头瘤病毒（HPV）感染的形态学证据。对12年间因子宫内膜癌切除的87份子宫切除标本切片以及术前刮宫标本进行复查，以检查是否存在棘皮瘤样改变以及是否有提示HPV感染的表现。这些女性的年龄在36岁至84岁之间，平均年龄为62.6岁。光镜检查显示，在一些肿瘤中，鳞状上皮和腺上皮均存在核周空泡化、乳头形成以及核内嗜酸性包涵体。免疫细胞化学和DNA原位杂交表明鳞状细胞和腺细胞中存在HPV抗原，并且在有核包涵体的细胞的电镜检查中可见到具有HPV特征的核周病毒颗粒。HPV可能直接从宫颈感染子宫内膜腺癌，但它不太可能具有病因学作用。然而，有可能该病毒除了作为“过客”之外，还可能刺激一些子宫内膜腺癌中的鳞状化生，并且也可能对其生物学行为产生一些影响。
