Alberhasky R C, Connelly P J, Christopherson W M
Am J Clin Pathol. 1982 Jun;77(6):655-64. doi: 10.1093/ajcp/77.6.655.
In a histologic review of 989 cases of invasive endometrial carcinomas there were 68 mixed adenosquamous carcinomas. Sixty were followed for at least five years, or until death. The other eight were diagnosed in 1976 and were ineligible for five-year status evaluation. Twenty-eight of the 60 patients or 46.7% were alive at five years. Twenty-five or 41.7% died of their cancer. Stage of disease, depth of myometrial invasion, vascular invasion, age, and method of treatment all had an impact on end results. By comparison, the absolute five-year survival rate for 200 women with adenocanthoma was 87.0%. Thirty patients with atypia of the squamous portion of the adenoacanthoma had an identical survival rate as those without atypia. Combined irradiation and hysterectomy end results were superior to hysterectomy only, or to radiation therapy only. Although one examination of time trends revealed a significant increase in the percentage of all tumors that were diagnosed as adenoacanthoma, there was no increase in the relative frequency of mixed adenosquamous carcinoma.
在对989例浸润性子宫内膜癌的组织学检查中，有68例为腺鳞混合癌。其中60例随访至少5年，或直至死亡。另外8例于1976年确诊，不符合5年状态评估条件。60例患者中有28例（46.7%）在5年后存活。25例（41.7%）死于癌症。疾病分期、肌层浸润深度、血管浸润、年龄和治疗方法均对最终结果有影响。相比之下，200例腺棘皮癌女性患者的绝对5年生存率为87.0%。30例腺棘皮癌鳞状部分有异型性的患者与无异型性的患者生存率相同。联合放疗和子宫切除术的最终结果优于单纯子宫切除术或单纯放疗。尽管一项时间趋势检查显示，所有被诊断为腺棘皮癌的肿瘤百分比显著增加，但腺鳞混合癌的相对频率并未增加。
