MAP3738c 和 MptD 是Ⅰ型糖尿病中感染分枝杆菌副结核亚种的特异性标记物。
MAP3738c and MptD are specific tags of Mycobacterium avium subsp. paratuberculosis infection in type I diabetes mellitus.
机构信息
Department of Biomedical Sciences, Division of Experimental and Clinical Microbiology, University of Sassari, Sassari, Italy.
出版信息
Clin Immunol. 2011 Oct;141(1):49-57. doi: 10.1016/j.clim.2011.05.002. Epub 2011 May 14.
Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of Johne's disease, a chronic inflammation of ruminants' intestine. Recent studies have linked Map to type I Diabetes mellitus (T1DM). We searched the presence of antibodies against two specific proteins of Map (MptD and MAP3738c) in sera of patients affected by T1DM and type II Diabetes mellitus (T2DM). MptD protein (MAP3733c) has been recognized as a Map virulent factor whereas MAP3738c has not yet been studied. Both proteins are encoded by genes belonging to a Map specific pathogenicity island. Forty three T1DM patients' sera, 56 T2DM patients' sera and 48 healthy subjects' sera were screened by ELISA to evaluate the immunoresponse against MptD or MAP3738c recombinant proteins. Results showed a positive response to both proteins in T1DM patients whereas no difference with controls was found for T2DM patients. Results suggest a potential relation between T1DM and the bacterial infection.
鸟分枝杆菌亚种副结核（Map）是引起约翰氏病的病原体，这是一种反刍动物肠道的慢性炎症。最近的研究将 Map 与 I 型糖尿病（T1DM）联系起来。我们在患有 T1DM 和 II 型糖尿病（T2DM）的患者的血清中搜索了针对 Map 两种特定蛋白质（MptD 和 MAP3738c）的抗体的存在。MptD 蛋白（MAP3733c）已被认为是 Map 的毒力因子，而 MAP3738c 尚未得到研究。这两种蛋白质均由属于 Map 特异性致病性岛的基因编码。通过 ELISA 筛选了 43 例 T1DM 患者的血清、56 例 T2DM 患者的血清和 48 例健康受试者的血清，以评估针对 MptD 或 MAP3738c 重组蛋白的免疫反应。结果显示，T1DM 患者对这两种蛋白质均呈阳性反应，而 T2DM 患者与对照组无差异。结果提示 T1DM 与细菌感染之间存在潜在的关系。
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