Faculty of Pharmacy, Masaryk University, 612 00 Brno, Czech Republic.
Orlova Department, Karvina-Raj Hospital, 734 01 Karvina, Czech Republic.
Int J Mol Sci. 2022 Mar 26;23(7):3657. doi: 10.3390/ijms23073657.
Civilization factors are responsible for the increasing of human exposure to mycobacteria from environment, water, and food during the last few decades. Urbanization, lifestyle changes and new technologies in the animal and plant industry are involved in frequent contact of people with mycobacteria. Type 1 diabetes is a multifactorial polygenic disease; its origin is conditioned by the mutual interaction of genetic and other factors. The environmental factors and certain pathogenetic pathways are shared by some immune mediated chronic inflammatory and autoimmune diseases, which are associated with triggers originating mainly from subspecies , an intestinal pathogen which persists in the environment. Type 1 diabetes and some other chronic inflammatory diseases thus pose the global health problem which could be mitigated by measures aimed to decrease the human exposure to this neglected zoonotic mycobacterium.
文明因素导致人类在过去几十年中越来越多地接触来自环境、水和食物中的分枝杆菌。城市化、生活方式的改变以及动植物产业中的新技术使人们经常与分枝杆菌接触。1 型糖尿病是一种多因素多基因疾病；其起源受遗传和其他因素相互作用的影响。环境因素和某些发病途径是一些免疫介导的慢性炎症性和自身免疫性疾病所共有的，这些疾病与主要起源于肠道病原体的环境持续存在的亚种的触发因素有关。1 型糖尿病和一些其他慢性炎症性疾病因此构成了全球健康问题，可以通过旨在减少人类接触这种被忽视的人畜共患病分枝杆菌的措施加以缓解。
