维生素 D 在皮肤中的代谢和功能。
Vitamin D metabolism and function in the skin.
机构信息
Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA.
出版信息
Mol Cell Endocrinol. 2011 Dec 5;347(1-2):80-9. doi: 10.1016/j.mce.2011.05.017. Epub 2011 Jun 1.
Abstract
The keratinocytes of the skin are unique in being not only the primary source of vitamin D for the body, but in possessing the enzymatic machinery to metabolize vitamin D to its active metabolite 1,25(OH)(2)D. Furthermore, these cells also express the vitamin D receptor (VDR) that enables them to respond to the 1,25(OH)(2)D they produce. Numerous functions of the skin are regulated by 1,25(OH)(2)D and/or its receptor. These include inhibition of proliferation, stimulation of differentiation including formation of the permeability barrier, promotion of innate immunity, and promotion of the hair follicle cycle. Regulation of these actions is exerted by a number of different coregulators including the coactivators DRIP and SRC, the cosuppressor hairless (Hr), and β-catenin. This review will examine the regulation of vitamin D production and metabolism in the skin, and explore the various functions regulated by 1,25(OH)(2)D and its receptor.
摘要
皮肤的角质形成细胞是独特的，不仅是身体维生素 D 的主要来源，而且还具有将维生素 D 代谢为其活性代谢物 1,25(OH)(2)D 的酶机制。此外，这些细胞还表达维生素 D 受体 (VDR)，使它们能够对自身产生的 1,25(OH)(2)D 作出反应。皮肤的许多功能都受到 1,25(OH)(2)D 和/或其受体的调节。这些功能包括抑制增殖、刺激分化（包括形成渗透性屏障）、促进先天免疫和促进毛囊周期。这些作用的调节是通过许多不同的共调节剂来实现的，包括共激活剂 DRIP 和 SRC、负调节剂 hairless (Hr) 和 β-连环蛋白。本文将探讨皮肤中维生素 D 产生和代谢的调节，并探讨 1,25(OH)(2)D 和其受体调节的各种功能。
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