Department of Psychology, University of Pennsylvania, PA 19104-6241, USA.
Clin Psychol Rev. 2011 Aug;31(6):923-33. doi: 10.1016/j.cpr.2011.05.001. Epub 2011 May 15.
Intolerance of uncertainty (IU) has been suggested to reflect a specific risk factor for generalized anxiety disorder (GAD), but there have been no systematic attempts to evaluate the specificity of IU to GAD. This meta-analysis examined the cross-sectional association of IU with symptoms of GAD, major depressive disorder (MDD), and obsessive-compulsive disorder (OCD). Random effects analyses were conducted for two common definitions of IU, one that has predominated in studies of GAD (56 effect sizes) and another that has been favored in studies of OCD (29 effect sizes). Using the definition of IU developed for GAD, IU shared a mean correlation of .57 with GAD, .53 with MDD, and .50 with OCD. Using the alternate definition developed for OCD, IU shared a mean correlation of .46 with MDD and .42 with OCD, with no studies available for GAD. Post-hoc significance tests revealed that IU was more strongly related to GAD than to OCD when the GAD-specific definition of IU was used. No other differences were found in the magnitude of associations between IU and the three syndromes. We discuss implications of these findings for models of shared and specific features of emotional disorders and for future research efforts.
不确定性容忍度 (IU) 被认为是广泛性焦虑症 (GAD) 的一个特定风险因素，但尚未有系统的尝试来评估 IU 对 GAD 的特异性。本荟萃分析检查了 IU 与 GAD、重度抑郁症 (MDD) 和强迫症 (OCD) 症状的横断面关联。对 IU 的两种常见定义进行了随机效应分析，一种是在 GAD 研究中占主导地位的定义（56 个效应量），另一种是在 OCD 研究中更受欢迎的定义（29 个效应量）。使用为 GAD 开发的 IU 定义，IU 与 GAD 的平均相关系数为.57，与 MDD 的平均相关系数为.53，与 OCD 的平均相关系数为.50。使用为 OCD 开发的替代 IU 定义，IU 与 MDD 的平均相关系数为.46，与 OCD 的平均相关系数为.42，而 GAD 则没有相关研究。事后显著性检验表明，当使用 GAD 特异性 IU 定义时，IU 与 GAD 的相关性强于与 OCD 的相关性。在 IU 与这三种综合征之间的关联程度方面没有发现其他差异。我们讨论了这些发现对情绪障碍共享和特定特征模型以及未来研究工作的影响。
