Choudhary Kanika, Mason Geneva, Correa Alethea, Fotinos Kathryn, Lokuge Sachinthya, Greifenberger Alexandria, Toumeh Elssa, Clarissa Sherinne, Epstein Irvin, Sternat Tia, Katzman Martin A
S.T.A.R.T. Clinic for Mood and Anxiety Disorders, 32 Park Road, Toronto, Ontario M4W 2N4, Canada.
University of Toronto Department of Family and Community Medicine, 500 University Ave, 5th Floor, Toronto, Ontario M5G 1V7, Canada.
J Mood Anxiety Disord. 2023 Aug 19;3:100019. doi: 10.1016/j.xjmad.2023.100019. eCollection 2023 Oct.
Major Depressive Disorder (MDD) is the leading cause of disability worldwide, affecting 3.8% of the global population. Despite its prevalence, less than half of those diagnosed with MDD receive treatment and remission rates remain low. Given these poor outcomes for individuals with depression and the findings of our previous study examining the role of certain psychological phenomena on the incidence of obsessive-compulsive disorder (OCD), the present study aims to examine whether intolerance of uncertainty, perfectionism, and coping strategies can together predict the diagnosis and severity of MDD. Participants were outpatients ( = 549) referred to a tertiary care clinic in Toronto, Canada between 2011 and 2014. After undergoing a diagnostic assessment, participants were administered a series of self-report questionnaires that measured intolerance of uncertainty, perfectionism, and coping. Results demonstrate that task-oriented coping and emotion-oriented coping significantly predicted depression diagnosis, while avoidant coping, perfectionism, and intolerance of uncertainty did not. As for depression severity, significant predictors included perfectionism, task-oriented coping, emotion-oriented coping, and avoidant coping. Further research is needed to identify interactions between the subscales of these constructs to determine how they work in tandem to influence MDD. Our findings indicate a need for more personalized interventions in the treatment of this disorder.
重度抑郁症（MDD）是全球致残的主要原因，影响着3.8%的全球人口。尽管其患病率很高，但不到一半的MDD确诊患者接受治疗，缓解率仍然很低。鉴于抑郁症患者的这些不良预后以及我们之前研究某些心理现象对强迫症（OCD）发病率作用的研究结果，本研究旨在探讨对不确定性的不耐受、完美主义和应对策略是否能共同预测MDD的诊断和严重程度。参与者为2011年至2014年期间转诊至加拿大多伦多一家三级护理诊所的门诊患者（n = 549）。在接受诊断评估后，参与者接受了一系列自我报告问卷，这些问卷测量了对不确定性的不耐受、完美主义和应对方式。结果表明，任务导向型应对和情绪导向型应对显著预测了抑郁症诊断，而回避型应对、完美主义和对不确定性的不耐受则没有。至于抑郁症严重程度，显著的预测因素包括完美主义、任务导向型应对、情绪导向型应对和回避型应对。需要进一步研究来确定这些构念子量表之间的相互作用，以确定它们如何协同作用来影响MDD。我们的研究结果表明，在这种疾病的治疗中需要更多个性化干预措施。
