Department of Preventive Medicine & Public Health & Medical Immunology & Microbiology, Rey Juan Carlos University, Madrid, Spain.
Vaccine. 2011 Aug 5;29(34):5765-70. doi: 10.1016/j.vaccine.2011.05.089. Epub 2011 Jun 12.
All hospital discharges and deaths related to invasive meningococcal disease, meningococcal meningitis and meningococcemia in the general population from 1997 to 2008 in Spain were obtained. Among the 11,611 meningococcal infection related discharges 53% were meningococcal meningitis and 55% were meningococcemia. The annual hospitalization rate was 2.33, 1.23 and 1.29 cases per 100,000 for invasive meningococcal disease, meningococcal meningitis and meningococcemia, respectively. 846 deaths for invasive meningococcal disease, 235 for meningococcal meningitis and 605 for meningococcemia were reported. Although an important decrease in meningococcal infections related morbidity and mortality has occurred in the last twelve years in Spain, they still continue being major causes of hospitalization and death, especially in the children up to 2 years of age. Future preventive measures, such as vaccination with vaccines covering new conjugated serogroups (B and ACYW135), could further improve population health.
获取了 1997 年至 2008 年期间西班牙普通人群中与侵袭性脑膜炎球菌病、脑膜炎球菌性脑膜炎和脑膜炎球菌血症相关的所有医院出院和死亡病例。在 11611 例与脑膜炎球菌感染相关的出院病例中，53%为脑膜炎球菌性脑膜炎，55%为脑膜炎球菌血症。侵袭性脑膜炎球菌病、脑膜炎球菌性脑膜炎和脑膜炎球菌血症的年住院率分别为每 10 万人 2.33、1.23 和 1.29 例。报告了 846 例侵袭性脑膜炎球菌病死亡病例、235 例脑膜炎球菌性脑膜炎死亡病例和 605 例脑膜炎球菌血症死亡病例。尽管在过去的十二年中，西班牙脑膜炎球菌感染的发病率和死亡率有了显著下降，但它们仍然是导致住院和死亡的主要原因，尤其是在 2 岁以下的儿童中。未来的预防措施，如接种覆盖新结合血清群（B 和 ACYW135）的疫苗，可能会进一步改善人群健康。
