Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Biochimie. 2011 Nov;93(11):1987-92. doi: 10.1016/j.biochi.2011.05.026. Epub 2011 Jun 2.
Small nucleolar RNAs (snoRNAs) are an ancient class of small non-coding RNAs present in all eukaryotes and a subset of archaea that carry out a fundamental role in the modification and processing of ribosomal RNA. In recent years, however, a large proportion of snoRNAs have been found to be further processed into smaller molecules, some of which display different functionality. In parallel, several studies have uncovered extensive similarities between snoRNAs and other types of small non-coding RNAs, and in particular microRNAs. Here, we explore the extent of the relationship between these types of non-coding RNA and the possible underlying evolutionary forces that shaped this subset of the current non-coding RNA landscape.
小核仁 RNA（snoRNAs）是一类古老的小分子非编码 RNA，存在于所有真核生物和部分古菌中，在核糖体 RNA 的修饰和加工中发挥着基本作用。然而，近年来发现大量 snoRNAs 进一步被加工成更小的分子，其中一些具有不同的功能。与此同时，几项研究揭示了 snoRNAs 与其他类型的小分子非编码 RNA，特别是 microRNAs 之间存在广泛的相似性。在这里，我们探讨了这些类型的非编码 RNA 之间的关系程度以及可能塑造当前非编码 RNA 景观这一亚类的潜在进化力量。
