Chang Gregory, Sherman Orrin, Madelin Guillaume, Recht Michael, Regatte Ravinder
Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG), Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, 660 First Avenue, Room 231, New York, NY 10016, USA.
Magn Reson Imaging Clin N Am. 2011 May;19(2):323-37. doi: 10.1016/j.mric.2011.02.002.
Because articular cartilage is avascular and has no intrinsic capacity to heal itself, physical damage to cartilage poses a serious clinical problem for orthopedic surgeons and rheumatologists. No medication exists to treat or reconstitute physical defects in articular cartilage, and pharmacotherapy is limited to pain control. Developments in the field of articular cartilage repair include microfracture, osteochondral autografting, osteochondral allografting, repair with synthetic resorbable plugs, and autologous chondrocyte implantation. MR imaging techniques have the potential to allow in vivo monitoring of the collagen and proteoglycan content of cartilage repair tissue and may provide useful additional metrics of cartilage repair tissue quality.
由于关节软骨无血管且自身没有修复能力，软骨的物理损伤给骨科医生和风湿病学家带来了严重的临床问题。目前尚无治疗或修复关节软骨物理缺损的药物，药物治疗仅限于控制疼痛。关节软骨修复领域的进展包括微骨折、自体骨软骨移植、异体骨软骨移植、使用可吸收合成塞修复以及自体软骨细胞植入。磁共振成像技术有可能实现对软骨修复组织中胶原蛋白和蛋白聚糖含量的体内监测，并可能提供有关软骨修复组织质量的有用额外指标。
