Department of Pathology, Tochigi Institute of Clinical Pathology, Tochigi 329-0112, Japan.
Cytokine. 2011 Sep;55(3):339-42. doi: 10.1016/j.cyto.2011.05.014. Epub 2011 Jun 12.
Endometriosis is a common gynecological disorder associated with infertility. However, treatment options remain limited at present. Since the pathogenesis involves immune responses, the immunomodulatory effect of macrolide on endometriosis has been the focus of much research. A previous study showed that clarithromycin decreased stromal proliferation and promoted apoptosis of fibroblasts in an endometriosis model in rats; however, the mechanism of the effect remains unknown. The aim of this study is to investigate the effect of clarithromycin, one of the major macrolides, and telithromycin, one of the antibiotics belonging to a macrolide group (ketolide), on IL6, IL10 and Ccl2 expression in a rat endometriosis model induced by the surgical transplantation of endometrium onto the peritoneum in 8-week-old female Sprague-Dawley rats. After autotransplantation, the rats were given daily administration of clarithromycin (16 mg/kg/day or telithromycin (12 mg/kg/day) for 3 days. The induced lesions were examined 4 days after autotransplantation. After treatment, IL10 expression in the lesions was increased in rats treated with clarithromycin (1.70-fold) and telithromycin (2.88-fold). The drugs attenuated proliferative stromal lesion of the endometriosis model. The results showed that in the endometriosis model, the drugs enhanced expression of IL10, which may play a role in inhibiting excess inflammatory reaction with its therapeutic effect on the lesion. Macrolide and ketolide therapy may have significant value for the treatment of human endometriosis.
子宫内膜异位症是一种常见的妇科疾病，与不孕有关。然而，目前的治疗选择仍然有限。由于发病机制涉及免疫反应，大环内酯类药物对子宫内膜异位症的免疫调节作用一直是研究的焦点。先前的一项研究表明，克拉霉素可减少大鼠子宫内膜异位症模型中基质细胞的增殖并促进成纤维细胞的凋亡；然而，其作用机制尚不清楚。本研究旨在探讨克拉霉素（一种主要的大环内酯类抗生素）和泰利霉素（一种属于大环内酯类抗生素的抗生素（酮内酯））对在 8 周龄雌性 Sprague-Dawley 大鼠腹膜内移植子宫内膜诱导的子宫内膜异位症模型中 IL6、IL10 和 Ccl2 表达的影响。自体移植后，大鼠每天给予克拉霉素（16mg/kg/天）或泰利霉素（12mg/kg/天）治疗 3 天。在自体移植后 4 天检查诱导的病变。治疗后，克拉霉素（1.70 倍）和泰利霉素（2.88 倍）处理的大鼠病变中 IL10 表达增加。这些药物减轻了子宫内膜异位症模型的增殖性基质病变。结果表明，在子宫内膜异位症模型中，这些药物增强了 IL10 的表达，这可能在抑制过度炎症反应中发挥作用，并发挥其对病变的治疗作用。大环内酯类和酮内酯类治疗可能对人类子宫内膜异位症的治疗具有重要价值。
