控制氧鎓叶立德的生成和反应的选择性。
Control of selectivity in the generation and reactions of oxonium ylides.
机构信息
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
出版信息
Chem Commun (Camb). 2011 Jul 21;47(27):7623-5. doi: 10.1039/c1cc12443a. Epub 2011 Jun 10.
PMID:21666901
Abstract
Dirhodium catalyzed reactions of aryl-substituted tetrahydropyranone diazoacetoacetates produce ylide intermediates that unexpectedly yield two oxabicyclo[4.2.1]-nonane diastereoisomers, but a single diastereoisomer is formed by increasing the steric bulk of the aryl substituent.
摘要
二铑催化取代的四氢吡喃酮重氮乙酰乙酸酯反应产生叶立德中间体，这些中间体出人意料地生成两种氧杂双环[4.2.1]壬烷非对映异构体，但增加芳基取代基的空间位阻时只会形成单一的非对映异构体。
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