Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Diabet Med. 2011 Oct;28(10):1194-200. doi: 10.1111/j.1464-5491.2011.03353.x.
Omentin-1 and chemerin have been identified as interesting novel adipokines that may modulate insulin action. Also, they have been suggested to be linked to obesity-induced insulin resistance. The aim of this study was to analyse the relationship between these adipokines and interleukin-6, insulin resistance and anthropometric and metabolic variables in patients with Type 2 diabetes mellitus and in patients with Type 2 diabetes who have ischaemic heart disease.
Seventy-five individuals with Type 2 diabetes and 15 healthy control subjects were enrolled in this study. Insulin levels, interleukin-6, omentin-1 and chemerin were measured by ELISA.
Serum omentin-1 levels were found to be significantly decreased in patients with Type 2 diabetes (19.7 ± 1 ng/ml) and in patients with Type 2 diabetes with ischaemic heart disease (18.5 ± 1.6 ng/ml) compared with healthy control subjects (27.4 ± 2.6 ng/ml) at P < 0.01. Moreover, serum chemerin levels were found to be significantly increased in patients with Type 2 diabetes (347 ± 14 ng/ml) and in patients with Type 2 diabetes with ischaemic heart disease (341 ± 16.5 ng/ml) compared with healthy control subjects (281 ± 13 ng/ml) at P < 0.01. Interestingly, omentin-1 and chemerin levels were found to be significantly correlated negatively with each other as well as being individually correlated with some selected anthropometric, biochemical and clinical variables. In conclusion, both omentin-1 and chemerin might play as a pivotal role in obesity and its associated disorders as Type 2 diabetes; however, their role in cardiovascular diseases needs to be fully elucidated.
内脂素-1 和趋化素已被确定为具有调节胰岛素作用的新型脂肪因子。此外，它们与肥胖引起的胰岛素抵抗有关。本研究旨在分析 2 型糖尿病患者和合并缺血性心脏病的 2 型糖尿病患者中这些脂肪因子与白细胞介素-6、胰岛素抵抗以及人体测量和代谢变量之间的关系。
本研究纳入了 75 例 2 型糖尿病患者和 15 例健康对照者。采用 ELISA 法检测胰岛素水平、白细胞介素-6、内脂素-1 和趋化素。
与健康对照组（27.4 ± 2.6 ng/ml）相比，2 型糖尿病患者（19.7 ± 1 ng/ml）和合并缺血性心脏病的 2 型糖尿病患者（18.5 ± 1.6 ng/ml）血清内脂素-1 水平显著降低（P < 0.01）。此外，与健康对照组（281 ± 13 ng/ml）相比，2 型糖尿病患者（347 ± 14 ng/ml）和合并缺血性心脏病的 2 型糖尿病患者（341 ± 16.5 ng/ml）血清趋化素水平显著升高（P < 0.01）。有趣的是，内脂素-1 和趋化素水平之间存在显著负相关，并且与一些选定的人体测量、生化和临床变量呈独立相关。结论：内脂素-1 和趋化素可能在肥胖及其相关疾病（如 2 型糖尿病）中发挥关键作用；然而，它们在心血管疾病中的作用仍需进一步阐明。
