Guzel Eda Celik, Celik Cem, Abali Remzi, Kucukyalcin Volkan, Celik Elcin, Guzel Murat, Yilmaz Murat
Department of Family Medicine .
Gynecol Endocrinol. 2014 Jun;30(6):419-22. doi: 10.3109/09513590.2014.888412. Epub 2014 Feb 13.
We aimed to investigate whether overweight/obesity is associated with omentin and chemerin. The study group consisted of 81 women with Polycystic ovarian syndrome (PCOS) (41 lean, BMI < 25 kg/m² and 40 overweight or obese, BMI > 25 kg/m²) and 61 healthy subjects (31 lean, BMI < 25 kg/m² and 30 overweight or obese, BMI > 25 kg/m²; control group). The clinical, endocrine, metabolic parameters, plasma omentin and chemerin levels were measured in patients and compared to control. In all subjects with PCOS (n = 80), serum chemerin levels were higher compared with those of the controls (n = 58) (7.71 ± 1.78 ng/mL versus 6.94 ± 0.82 ng/mL, p = 0.003). However, serum omentin levels were not significantly different between the PCOS subjects and the controls (1.55 ± 0.43 ng/mL versus 1.69 ± 0.37 ng/mL, p = 0.056). The mean chemerin concentrations were significantly elevated in the obese PCOS group compared with the obese control subjects (8.98 ± 1.45 ng/mL versus 7.02 ± 0.67 ng/mL, p = 0.000) and the nonobese PCOS group compared with the obese control subjects (6.57 ± 1.17 ng/mL versus 7.02 ± 0.67 ng/mL, p = 0.000). In conclusion, fat mass seems to be the main determinant factor of increased chemerin and decreased omentin in women with PCOS.
我们旨在研究超重/肥胖是否与网膜素和卡莫林有关。研究组由81名多囊卵巢综合征（PCOS）女性组成（41名体重正常，BMI＜25kg/m²，40名超重或肥胖，BMI＞25kg/m²）以及61名健康受试者（31名体重正常，BMI＜25kg/m²，30名超重或肥胖，BMI＞25kg/m²；对照组）。对患者的临床、内分泌、代谢参数、血浆网膜素和卡莫林水平进行了测量，并与对照组进行比较。在所有PCOS受试者（n = 80）中，血清卡莫林水平高于对照组（n = 58）（7.71±1.78ng/mL对6.94±0.82ng/mL，p = 0.003）。然而，PCOS受试者与对照组之间的血清网膜素水平无显著差异（1.55±0.43ng/mL对1.69±0.37ng/mL，p = 0.056）。与肥胖对照组相比，肥胖PCOS组的平均卡莫林浓度显著升高（8.98±1.45ng/mL对7.02±0.67ng/mL，p = 0.000），与肥胖对照组相比，非肥胖PCOS组的平均卡莫林浓度也显著升高（6.57±1.17ng/mL对7.02±0.67ng/mL，p = 0.000）。总之，脂肪量似乎是PCOS女性卡莫林升高和网膜素降低的主要决定因素。
