Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid, Saint Louis, MO 63110, USA.
Addict Biol. 2011 Jul;16(3):514-8. doi: 10.1111/j.1369-1600.2010.00255.x. Epub 2010 Nov 4.
Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence.
尽管双胞胎研究表明，DSM-IV 大麻依赖的 50-70%的变异可归因于遗传影响，但对于影响大麻依赖易感性的特定基因型知之甚少。我们进行了 DSM-IV 大麻依赖的全基因组关联研究。使用 PLINK 中的逻辑回归对 708 例 DSM-IV 大麻依赖病例和 2346 例大麻暴露非依赖对照进行了关联分析。948142 个单核苷酸多态性中没有一个达到全基因组显著性（E-8 处的 P 值）。在 ANKFN1 基因中，染色体 17 上的多态性（rs1019238 和 rs1431318，E-7 处的 P 值）获得了最低的 P 值。虽然需要进行复制，但这项研究代表了阐明大麻依赖生物学基础的重要的第一步。
