Guan J, Yi H, Wu X, Su K, Tao M, Yin S
Department of Otolaryngology, The Affiliated Sixth People's Hospital, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, China.
J Laryngol Otol. 2011 Oct;125(10):1042-8. doi: 10.1017/S002221511100123X. Epub 2011 Jun 14.
Peroxisome proliferator activated receptor gamma is a ligand-dependent transcription factor with an important role in insulin resistance and obesity. We investigated the associations between the Pro12Ala polymorphism of this receptor, obstructive sleep apnoea hypopnoea syndrome and hyperlipidaemia risk factors, in a Chinese cohort.
We recruited 420 obstructive sleep apnoea hypopnoea syndrome patients and 190 healthy controls. Genetic analysis was conducted by restriction fragment length polymorphism. The hyperlipidaemia risk in both the study and control groups was analysed.
Comparison of genotype and allele frequencies revealed no significant differences between patients and controls (p > 0.05). In patients, there was no correlation between genotype and clinical parameters (p > 0.05), apart from a significant association between the Ala12 allele and hyperlipidaemia (odds ratio = 2.181; p = 0.017; 95 per cent confidence interval = 1.133-4.198).
In this Chinese cohort, the Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma was not associated with obstructive sleep apnoea hypopnoea syndrome, but was associated with increased hyperlipidaemia risk.
过氧化物酶体增殖物激活受体γ是一种配体依赖性转录因子，在胰岛素抵抗和肥胖中起重要作用。我们在中国人群队列中研究了该受体的Pro12Ala多态性与阻塞性睡眠呼吸暂停低通气综合征及高脂血症危险因素之间的关联。
我们招募了420例阻塞性睡眠呼吸暂停低通气综合征患者和190例健康对照者。采用限制性片段长度多态性进行基因分析。对研究组和对照组的高脂血症风险进行了分析。
基因型和等位基因频率比较显示患者与对照者之间无显著差异（p>0.05）。在患者中，除Ala12等位基因与高脂血症之间存在显著关联外（比值比=2.181；p=0.017；95%置信区间=1.133 - 4.198），基因型与临床参数之间无相关性（p>0.05）。
在这个中国人群队列中，过氧化物酶体增殖物激活受体γ的Pro12Ala多态性与阻塞性睡眠呼吸暂停低通气综合征无关，但与高脂血症风险增加有关。
