Rotman Research Institute, Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada.
Behav Brain Res. 2012 Feb 14;227(2):464-9. doi: 10.1016/j.bbr.2011.05.032. Epub 2011 Jun 6.
Rats, subjected to low-dose irradiation that suppressed hippocampal neurogenesis, or a sham treatment, were administered a visual discrimination task under conditions of high, or low interference. Half of the rats engaged in running activity and the other half did not. In the non-runners, there was no effect of irradiation on learning, or remembering the discrimination response under low interference, but irradiation treatment increased their susceptibility to interference, resulting in loss of memory for the previously learned discrimination. Irradiated rats that engaged in running activity exhibited increased neuronal growth and protection from memory impairment. The results, which show that hippocampal cells generated in adulthood play a role in differentiating between conflicting, context-dependent memories, provide further evidence of the importance of neurogenesis in hippocampus-sensitive memory tasks. The results are consistent with computational models of hippocampal function that specify a central role for neurogenesis in the modulation of interfering influences during learning and memory.
大鼠接受低剂量辐射抑制海马神经发生，或假处理，然后在高干扰或低干扰条件下进行视觉辨别任务。一半的大鼠进行跑步活动，另一半不进行。在非跑步大鼠中，辐射对学习或在低干扰下记忆辨别反应没有影响，但辐射处理增加了它们对干扰的敏感性，导致先前学习的辨别记忆丧失。进行跑步活动的辐射大鼠表现出神经元生长增加和免受记忆障碍的保护。这些结果表明，成年期产生的海马细胞在区分冲突的、依赖于上下文的记忆方面发挥作用，进一步证明了神经发生在海马敏感记忆任务中的重要性。这些结果与海马功能的计算模型一致，该模型指定了神经发生在学习和记忆过程中调节干扰影响的核心作用。
