金纳米棒介导的等离子体光热疗法：增强大分子递呈的工具。
Gold nanorod mediated plasmonic photothermal therapy: a tool to enhance macromolecular delivery.
机构信息
Department of Bioengineering, University of Utah, Salt Lake City, UT 84108, USA.
出版信息
Int J Pharm. 2011 Aug 30;415(1-2):315-8. doi: 10.1016/j.ijpharm.2011.05.068. Epub 2011 Jun 12.
Abstract
Plasmonic photothermal therapy (PPTT) with gold nanostructures has been used to generate significant heat within tumors to ablate vasculature. Here we report the use of gold nanorod (GNR) mediated PPTT to induce moderate hyperthermia as a tool to enhance the delivery of macromolecules. GNRs were injected intravenously in a mouse sarcoma (S-180) tumor model. After 24h Evans blue dye (EBD) was injected and the right tumor was radiated with a laser diode for 10 min. EBD content in the right and left tumors were extracted in formamide, measured spectrophotometrically and expressed as a thermal enhancement ratio (TER). Enhanced delivery of EBD was observed (up to 1.8-fold) when tumor temperatures reached 43°C or 46°C. No statistical difference was observed between tumors at these two temperatures, though significant hemorrhage was observed in tumors and surrounding areas receiving the higher thermal dose (46°C). These results indicate that tumor directed PPTT may be used to induce moderate hyperthermia and therefore selectively increase the delivery of macromolecules with therapeutic anticancer drugs.
摘要
金纳米结构的等离子体光热疗法 (PPTT) 已被用于在肿瘤内产生大量热量以消融血管。在这里，我们报告了使用金纳米棒 (GNR) 介导的 PPTT 诱导适度热疗作为增强大分子递药的工具。GNRs 通过静脉内注射到小鼠肉瘤 (S-180) 肿瘤模型中。24 小时后，注射 Evans 蓝染料 (EBD)，并用激光二极管对右肿瘤照射 10 分钟。在甲酰胺中提取右和左肿瘤中的 EBD 含量，用分光光度法测量，并表示为热增强比 (TER)。当肿瘤温度达到 43°C 或 46°C 时，观察到 EBD 的递增强化（高达 1.8 倍）。虽然在接受更高热剂量（46°C）的肿瘤和周围区域观察到明显的出血，但这两个温度下的肿瘤之间没有观察到统计学差异。这些结果表明，肿瘤定向 PPTT 可用于诱导适度热疗，从而选择性地增加具有抗癌药物的大分子的递药。
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