Villuendas Helena, Vilches Clara, Quidant Romain
Nanophotonic Systems Laboratory, Department of Mechanical and Process Engineering, ETH Zürich, 8092 Zürich, Switzerland.
ICFO - Institut de Ciències Fotòniques, the Barcelona Institute of Science and Technology, 08860 Castelldefels, Barcelona, Spain.
ACS Nanosci Au. 2023 Jul 17;3(5):347-352. doi: 10.1021/acsnanoscienceau.3c00011. eCollection 2023 Oct 18.
Lack of standardization is a systematic problem that impacts nanomedicine by challenging data comparison from different studies. Translation from preclinical to clinical stages indeed requires reproducible data that can be easily accessed and compared. In this work, we propose a series of experimental standards for plasmonic photothermal therapy (PPTT). This best practice guide covers the five main aspects of PPTT studies nanomaterials, biological samples, pre-, during, and postirradiation characterization. We are confident that such standardization of experimental protocols and reported data will benefit the development of PPTT as a transversal therapy.
缺乏标准化是一个系统性问题，它通过对不同研究的数据比较提出挑战，从而影响纳米医学。从临床前阶段到临床阶段的转化确实需要可重复的数据，这些数据应易于获取和比较。在这项工作中，我们提出了一系列用于等离子体光热疗法（PPTT）的实验标准。本最佳实践指南涵盖了PPTT研究的五个主要方面——纳米材料、生物样本、辐照前、辐照期间和辐照后表征。我们相信，实验方案和报告数据的这种标准化将有利于PPTT作为一种横向疗法的发展。
