National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226, USA.
Reprod Toxicol. 2011 Nov;32(3):277-85. doi: 10.1016/j.reprotox.2011.05.012. Epub 2011 Jun 2.
The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone were assessed in a nationally representative sample of women, 35-60 years old, from the National Health and Nutrition Examination Survey 1999-2002. The blood lead levels of the women ranged from 0.2 to 17.0 μg/dL. The estimated geometric mean was 1.4 μg/dL, and the estimated arithmetic mean was 1.6 μg/dL. As the blood lead level increased, the concentration of serum follicle stimulating hormone increased in post-menopausal women, women who had both ovaries removed, and pre-menopausal women. The concentration of luteinizing hormone increased as blood lead level increased in post-menopausal women and women who had both ovaries removed. The lowest concentrations of blood lead at which a relationship was detected were 0.9 μg/dL for follicle stimulating hormone and 3.2 μg/dL for luteinizing hormone. Lead may act directly or indirectly at ovarian and non-ovarian sites to increase the concentrations of follicle stimulating hormone and luteinizing hormone.
在一项针对美国国家健康和营养调查研究 1999-2002 年期间 35-60 岁的具有代表性的女性样本中，评估了血液中铅含量与血清卵泡刺激素和黄体生成素之间的关系。女性的血液铅含量范围为 0.2 至 17.0μg/dL。估计的几何平均值为 1.4μg/dL，估计的算术平均值为 1.6μg/dL。随着血液铅含量的增加，在绝经后妇女、已切除卵巢的妇女和绝经前妇女中，血清卵泡刺激素的浓度增加。黄体生成素的浓度随着绝经后妇女和已切除卵巢的妇女血液铅含量的增加而增加。检测到关系的最低血液铅浓度分别为卵泡刺激素 0.9μg/dL 和黄体生成素 3.2μg/dL。铅可能直接或间接地在卵巢和非卵巢部位作用，以增加卵泡刺激素和黄体生成素的浓度。
