葡萄膜黑色素瘤细胞核RNA含量的流式细胞术测量

Flow cytometry measurement of nuclear RNA content in uveal melanoma.

作者信息

Chen T C, Char D H, Waldman F, Juster R P

机构信息

Department of Ophthalmology, University of California, San Francisco.

出版信息

Ophthalmic Res. 1990;22(3):187-93. doi: 10.1159/000267022.

DOI:10.1159/000267022

PMID:2166933

Abstract

We retrospectively studied the nuclear RNA content in uveal melanomas with known, long-term follow-up. Thirty patients had spindle cell melanomas, 25 had mixed cell tumors, and 9 had epithelioid cell neoplasms. Epithelioid cell types had a higher nuclear RNA content compared to mixed or spindle cell types (p less than 0.05). Using the Cox proportional hazards model, the nuclear RNA content appeared to be an independent prognostic indicator in uveal melanomas, and an increased nuclear RNA content was associated with a worse prognosis (p = 0.001).

摘要

我们对已知长期随访情况的葡萄膜黑色素瘤的核RNA含量进行了回顾性研究。30例患者患有梭形细胞黑色素瘤，25例患有混合细胞肿瘤，9例患有上皮样细胞瘤。与混合细胞型或梭形细胞型相比，上皮样细胞型的核RNA含量更高（p<0.05）。使用Cox比例风险模型，核RNA含量似乎是葡萄膜黑色素瘤的一个独立预后指标，核RNA含量增加与预后较差相关（p = 0.001）。