Hodge W G, Duclos A J, Rocha G, Antecka E, Baines M G, Corriveau C, Brownstein S, Deschenes J
Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.
Br J Ophthalmol. 1995 Jun;79(6):521-6. doi: 10.1136/bjo.79.6.521.
To predict 5 year survival in patients with uveal malignant melanomas DNA indices were studied.
Using 45 paraffin embedded uveal malignant melanomas, the DNA index and S phase fraction of each tumour were the predictor variables recorded.
Using the Cox proportional hazards model, aneuploid tumours and tumours which had an S phase fraction greater than 4% were significant predictors of early death. In order to demonstrate a biological gradient between a larger DNA index and shorter survival time, linear regression and transformed linear regression models were used. However, no such gradient could be demonstrated.
Although this study shows promise for the use of DNA studies in the prognosis of uveal malignant melanoma, the exact role of these techniques remains to be determined.
通过研究葡萄膜恶性黑色素瘤患者的DNA指数来预测其5年生存率。
采用45例石蜡包埋的葡萄膜恶性黑色素瘤，记录每个肿瘤的DNA指数和S期分数作为预测变量。
使用Cox比例风险模型，非整倍体肿瘤和S期分数大于4%的肿瘤是早期死亡的显著预测因素。为了证明较大的DNA指数与较短的生存时间之间存在生物学梯度，使用了线性回归和变换线性回归模型。然而，未能证明存在这样的梯度。
尽管本研究显示了DNA研究在葡萄膜恶性黑色素瘤预后中的应用前景，但这些技术的确切作用仍有待确定。
