重症肌无力中的伴随自身免疫——与 IgA 缺乏无关。
Concomitant autoimmunity in myasthenia gravis--lack of association with IgA deficiency.
机构信息
Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden.
出版信息
J Neuroimmunol. 2011 Jul;236(1-2):118-22. doi: 10.1016/j.jneuroim.2011.05.008. Epub 2011 Jun 12.
Abstract
A marked increase in concomitant autoimmune diseases has previously been noted in patients with myasthenia gravis (MG). We show that these diseases occur both before and after the onset of MG and that the process is not influenced by thymectomy. IgA deficiency (IgAD), which is strongly associated with the same HLA haplotype as early onset MG, has recently been suggested to be an autoimmune disease. However, there was no increase in the prevalence of IgAD in a large cohort of Swedish MG patients.
摘要
先前已经注意到重症肌无力（MG）患者同时患有自身免疫性疾病的比例显著增加。我们表明，这些疾病发生在 MG 之前和之后，并且该过程不受胸腺切除术的影响。最近有人提出，与早期发病的 MG 相同 HLA 单倍型密切相关的 IgA 缺乏症（IgAD）也是一种自身免疫性疾病。然而，在瑞典的大型 MG 患者队列中，IgAD 的患病率并没有增加。
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