Eusebi V, Damiani S, Riva C, Lloyd R V, Capella C
Institute of Anatomical and Histological Pathology, Bologna University, Italy.
Virchows Arch A Pathol Anat Histopathol. 1990;417(3):267-71. doi: 10.1007/BF01600144.
Two cases of primary oat-cell carcinoma of thyroid, in a 63-year-old woman and a 73-year-old man, are described. Case 1 was a compound tumour with the oat-cell component merging with a papillary component. Both tumours, in addition to histological features consistent with oat-cell carcinoma, showed immunohistochemical positivity with anti-chromagranin A and anti-synaptophysin antisera. Negative results were obtained when anti-calcitonin and anti-thyroglobulin antisera were employed. Using in situ hybridization, chromogranin A and B messenger RNAs were localized with biotinylated oligonucleotide probes. In contrast, with in situ hybridization, no localization for calcitonin messenger RNA was seen using radioactive and biotinylated probes. It is concluded that these calcitonin-free, small-cell carcinomas should be considered separately from medullary thyroid carcinomas and be regarded as a distinct entity, probably the thyroid equivalent of oat-cell carcinomas of the lung.
本文描述了两例原发性甲状腺燕麦细胞癌，患者分别为一名63岁女性和一名73岁男性。病例1是一种复合肿瘤，燕麦细胞成分与乳头状成分融合。除了具有与燕麦细胞癌一致的组织学特征外，这两种肿瘤对抗嗜铬粒蛋白A和抗突触素抗血清均呈免疫组化阳性。使用抗降钙素和抗甲状腺球蛋白抗血清时结果为阴性。采用原位杂交技术，用生物素化寡核苷酸探针定位嗜铬粒蛋白A和B信使核糖核酸。相比之下，采用原位杂交技术，使用放射性和生物素化探针均未发现降钙素信使核糖核酸的定位。结论是，这些无降钙素的小细胞癌应与甲状腺髓样癌分开考虑，并被视为一种独特的实体，可能相当于甲状腺的肺燕麦细胞癌。
