Qu Yuan, Zhang Yang, Pei Liang, Wang Yan, Gao Lijuan, Huang Qianming, Ojika Makoto, Sakagami Youji, Qi Jianhua
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Biosci Biotechnol Biochem. 2011;75(6):1201-4. doi: 10.1271/bbb.110066. Epub 2011 Jun 13.
A new steroidal saponin was isolated from Ophiopogon japonicus. This saponin possesses a modification by 2-hydroxy-3-methylvalerylation of the hydroxyl group at C-4' of the sugar, linked to C-1 of the aglycone. It exhibited significant neuritogenic activity for PC12 cells. The structure-activity relationship revealed the aglycone, rather than the sugar moieties and acylation, to be important for the neuritogenic activity.
从麦冬中分离出一种新的甾体皂苷。该皂苷在与苷元C-1相连的糖的C-4'位羟基上存在2-羟基-3-甲基戊酰化修饰。它对PC12细胞表现出显著的促神经突生长活性。构效关系表明，对于促神经突生长活性而言，苷元比糖部分和酰化更重要。
