来自麦冬（Ophiopogon japonicus (Thunb.) Ker-Gawl.）的新型促神经突生长甾体皂苷
New neuritogenic steroidal saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl.
作者信息
Qu Yuan, Zhang Yang, Pei Liang, Wang Yan, Gao Lijuan, Huang Qianming, Ojika Makoto, Sakagami Youji, Qi Jianhua
机构信息
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
出版信息
Biosci Biotechnol Biochem. 2011;75(6):1201-4. doi: 10.1271/bbb.110066. Epub 2011 Jun 13.
A new steroidal saponin was isolated from Ophiopogon japonicus. This saponin possesses a modification by 2-hydroxy-3-methylvalerylation of the hydroxyl group at C-4' of the sugar, linked to C-1 of the aglycone. It exhibited significant neuritogenic activity for PC12 cells. The structure-activity relationship revealed the aglycone, rather than the sugar moieties and acylation, to be important for the neuritogenic activity.
从麦冬中分离出一种新的甾体皂苷。该皂苷在与苷元C-1相连的糖的C-4'位羟基上存在2-羟基-3-甲基戊酰化修饰。它对PC12细胞表现出显著的促神经突生长活性。构效关系表明，对于促神经突生长活性而言，苷元比糖部分和酰化更重要。
Zotero 插件