Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Clin Microbiol Infect. 2011 Sep;17(9):1304-11. doi: 10.1111/j.1469-0691.2011.03574.x. Epub 2011 Jun 14.
Chorioamnionitis refers to inflammation of the amniochorionic membrane, and is a significant cause of maternal and neonatal morbidity. Chorioamnionitis most often occurs as a result of ascending infection, and is commonly associated with premature rupture of the membranes. Chorioamnionitis is generally the result of a polymicrobial infection, with Ureaplasma urealyticum, Mycoplasma hominis and Gram-negative anaerobes being frequent causative organisms. The mainstay of treatment includes antimicrobial agents, antipyretics, expedition of delivery and supportive care. Further research is required to identify mechanistic pathways and early biomarkers that accurately predict women at higher risk of adverse maternal and neonatal outcomes, and that can thus lead to the development of additional treatment and prevention strategies.
绒毛膜羊膜炎是指羊膜和绒毛膜的炎症，是导致母亲和新生儿发病率和死亡率的重要原因。绒毛膜羊膜炎最常由上行性感染引起，常与胎膜早破有关。绒毛膜羊膜炎通常是由多种微生物感染引起的，其中解脲脲原体、人型支原体和革兰氏阴性厌氧菌是常见的病原体。治疗的主要方法包括使用抗生素、退热剂、加速分娩和支持性护理。需要进一步研究来确定准确预测母亲和新生儿不良结局风险较高的女性的机制途径和早期生物标志物，从而开发出更多的治疗和预防策略。
