Abele-Horn M, Scholz M, Wolff C, Kolben M
Institute of Microbiology, Julius-Maximilians-University, Wuerzburg, Germany.
Acta Obstet Gynecol Scand. 2000 Nov;79(11):973-8.
The aim of this case control study was to investigate the influence of genital Ureaplasma urealyticum colonization on pregnancy outcome.
One hundred and seventy-two women colonized with Ureaplasma urealyticum without co-existing other infections and 123 women with negative cultures for Ureaplasma urealyticum were enrolled. In a multivariate analysis the influence of quantitative Ureaplasma urealyticum colonization level was determined.
Compared to the negative women increasing colonization with Ureaplasma urealyticum was associated with a significant decrease of birth weight (p<0.0001) and gestational age (p<0.0001) and with a significant increase of chorioamnionitis (p<0.0001) and preterm delivery (p<0.001). In a multivariate analysis high-density Ureaplasma urealyticum colonization was an independent risk factor for chorioamnionitis and preterm delivery, whereas low colonization levels had no effect on an adverse outcome of pregnancy.
The degree of colonization with Ureaplasma urealyticum correlates strongly with an adverse effect on pregnancy outcome.
本病例对照研究的目的是调查解脲脲原体生殖道定植对妊娠结局的影响。
纳入172例仅定植解脲脲原体而无其他合并感染的女性以及123例解脲脲原体培养阴性的女性。在多因素分析中确定了解脲脲原体定量定植水平的影响。
与阴性女性相比，解脲脲原体定植增加与出生体重显著降低（p<0.0001）、孕周显著缩短（p<0.0001）、绒毛膜羊膜炎显著增加（p<0.0001）以及早产显著增加（p<0.001）相关。在多因素分析中，高密度解脲脲原体定植是绒毛膜羊膜炎和早产的独立危险因素，而低定植水平对妊娠不良结局无影响。
解脲脲原体的定植程度与对妊娠结局的不良影响密切相关。
