Reed Frances, Burrow Rachel, Poels Katrien L C, Godderis Lode, Veulemans Hendrik A F, Mosing Martina
Small Animal Teaching Hospital, University of Liverpool, Neston, Cheshire, UK.
Vet Anaesth Analg. 2011 Jul;38(4):407-12. doi: 10.1111/j.1467-2995.2011.00628.x.
To investigate whether the method used to attach matrix-type fentanyl patches influences the degree of skin attachment and the amount of active drug remaining in patches after use.
Prospective, randomised clinical study.
Fifteen adult dogs of mixed breeds.
Two equally sized matrix-type fentanyl patches were attached to the dorsal third of the lateral thorax of fifteen dogs for 72 hours. The two patches were attached using different techniques: Method AD used an adhesive dressing in combination with a transparent film. Method TG used tissue adhesive applied to the edges of the patch. After 72 hours the patches were removed and the proportion of the patch attached at this time calculated. The residual content of the patches was analysed using a validated gas chromatography-mass spectrometery (GC-MS) analysis technique.
After 72 hours of continuous attachment, the mean proportion of drug uptake for method AD was 17.2 (SD ± 11.1)% and for method TG this was 16.9 (SD ± 7.3)%. The median proportion of attachment for method AD was 100% and for method TG was 95.6%.
The method of attachment did not significantly influence the uptake of fentanyl from matrix-type patches. The method of attachment resulted in a significant difference in the proportion of the patch attached 72 hours after placement, with method AD resulting in a greater median proportion of attachment than TG.
The method used to attach matrix-type fentanyl patches to dogs should not interfere with drug uptake. The residual fentanyl content remaining in these patches after 72 hours of continuous application is significant and could lead to intoxication if ingested by humans.
研究粘贴基质型芬太尼贴剂的方法是否会影响皮肤粘贴程度以及使用后贴剂中剩余的活性药物量。
前瞻性随机临床研究。
15只成年杂种犬。
将两片大小相同的基质型芬太尼贴剂贴于15只犬侧胸壁背侧三分之一处，持续72小时。两片贴剂采用不同技术粘贴：方法AD使用粘性敷料结合透明薄膜。方法TG使用组织粘合剂涂抹于贴剂边缘。72小时后取下贴剂，计算此时贴剂粘贴的比例。使用经过验证的气相色谱 - 质谱联用（GC - MS）分析技术分析贴剂的残留含量。
持续粘贴72小时后，方法AD的药物摄取平均比例为17.2（标准差±11.1）%，方法TG为16.9（标准差±7.3）%。方法AD的粘贴中位数比例为100%，方法TG为95.6%。
粘贴方法对基质型贴剂中芬太尼的摄取没有显著影响。粘贴方法导致放置72小时后贴剂粘贴比例存在显著差异，方法AD的粘贴中位数比例高于方法TG。
用于给犬粘贴基质型芬太尼贴剂的方法不应干扰药物摄取。持续应用72小时后这些贴剂中残留的芬太尼含量可观，如果被人类摄入可能导致中毒。
