建立和维持健康的阴道环境：定期预防性治疗阴道感染随机试验数据分析。
Establishing and sustaining a healthy vaginal environment: analysis of data from a randomized trial of periodic presumptive treatment for vaginal infections.
机构信息
Department of Epidemiology, University of Washington, Seattle, WA 98104, USA.
出版信息
J Infect Dis. 2011 Jul 15;204(2):323-6. doi: 10.1093/infdis/jir241.
Abstract
Data from a randomized trial of oral periodic presumptive treatment (PPT) to reduce vaginal infections were analyzed to assess the effect of the intervention on a healthy vaginal environment (normal flora confirmed by Gram stain with no candidiasis or trichomoniasis). The incidence of a healthy vaginal environment was 608 cases per 100 person-years in the intervention arm and 454 cases per 100 person-years in the placebo arm (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.17-1.58). Sustained vaginal health (healthy vaginal environment for ≥3 consecutive visits) was also more frequent in the intervention arm (HR, 1.69; 95% CI, 1.23-2.33). PPT is effective at establishing and sustaining a healthy vaginal environment.
摘要
对口服周期性推定治疗（PPT）减少阴道感染的随机试验数据进行了分析，以评估该干预措施对健康阴道环境（革兰氏染色证实无假丝酵母菌或滴虫感染的正常菌群）的影响。干预组中健康阴道环境的发生率为每 100 人年 608 例，安慰剂组为每 100 人年 454 例（风险比[HR]，1.36；95%置信区间[CI]，1.17-1.58）。干预组中持续的阴道健康（连续 3 次就诊时健康的阴道环境）也更为频繁（HR，1.69；95%CI，1.23-2.33）。PPT 可有效建立和维持健康的阴道环境。
相似文献
1
Establishing and sustaining a healthy vaginal environment: analysis of data from a randomized trial of periodic presumptive treatment for vaginal infections.建立和维持健康的阴道环境：定期预防性治疗阴道感染随机试验数据分析。
J Infect Dis. 2011 Jul 15;204(2):323-6. doi: 10.1093/infdis/jir241.
2
Randomized Trial of Periodic Presumptive Treatment With High-Dose Intravaginal Metronidazole and Miconazole to Prevent Vaginal Infections in HIV-negative Women.高剂量阴道用甲硝唑和咪康唑定期推定治疗预防HIV阴性女性阴道感染的随机试验
J Infect Dis. 2015 Jun 15;211(12):1875-82. doi: 10.1093/infdis/jiu818. Epub 2014 Dec 19.
3
Improvement of vaginal health for Kenyan women at risk for acquisition of human immunodeficiency virus type 1: results of a randomized trial.改善肯尼亚有感染1型人类免疫缺陷病毒风险的女性的阴道健康：一项随机试验的结果。
J Infect Dis. 2008 May 15;197(10):1361-8. doi: 10.1086/587490.
4
Periodic presumptive treatment for women with prevalent vaginal infections: secondary analysis of data from a randomized controlled trial.对患有常见阴道感染的女性进行定期推定治疗：一项随机对照试验数据的二次分析
Sex Transm Dis. 2014 Jul;41(7):453. doi: 10.1097/OLQ.0000000000000152.
5
European guideline for the management of vaginal discharge.欧洲阴道分泌物管理指南。
Int J STD AIDS. 2001 Oct;12 Suppl 3:73-7. doi: 10.1258/0956462011923985.
6
Vaginal infection: prophylaxis and perinatal outcome--a review of the literature.阴道感染：预防措施与围产期结局——文献综述
Int J Fertil Womens Med. 2000 Nov-Dec;45(6):358-67.
7
The posttrial effect of oral periodic presumptive treatment for vaginal infections on the incidence of bacterial vaginosis and Lactobacillus colonization.口服定期预防性治疗阴道感染对细菌性阴道病和乳酸杆菌定植发生率的试验后效应。
Sex Transm Dis. 2012 May;39(5):361-5. doi: 10.1097/OLQ.0b013e31824790d7.
8
Vulvovaginitis: screening for and management of trichomoniasis, vulvovaginal candidiasis, and bacterial vaginosis.外阴阴道炎：滴虫病、外阴阴道念珠菌病和细菌性阴道病的筛查与管理。
J Obstet Gynaecol Can. 2015 Mar;37(3):266-274. doi: 10.1016/S1701-2163(15)30316-9.
9
Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections.产过氧化氢乳酸杆菌与阴道感染的获得
J Infect Dis. 1996 Nov;174(5):1058-63. doi: 10.1093/infdis/174.5.1058.
10
Impact of Periodic Presumptive Treatment for Bacterial Vaginosis on the Vaginal Microbiome among Women Participating in the Preventing Vaginal Infections Trial.细菌性阴道病定期推定治疗对参与预防阴道感染试验女性阴道微生物群的影响
J Infect Dis. 2017 Mar 1;215(5):723-731. doi: 10.1093/infdis/jiw622.
引用本文的文献
1
New insights toward personalized therapies for vulvovaginal candidiasis and vaginal co-infections.外阴阴道念珠菌病和阴道合并感染个性化治疗的新见解。
Front Microbiol. 2025 Aug 8;16:1625952. doi: 10.3389/fmicb.2025.1625952. eCollection 2025.
2
A study on vaginitis among pregnant and non-pregnant females in Alexandria, Egypt: An unexpected high rate of mixed vaginal infection.埃及亚历山大孕妇与非孕妇阴道炎研究：意外的高混合性阴道感染率
AIMS Microbiol. 2022 May 5;8(2):167-177. doi: 10.3934/microbiol.2022014. eCollection 2022.
3
Temporal Changes in Vaginal Microbiota and Genital Tract Cytokines Among South African Women Treated for Bacterial Vaginosis.南非细菌性阴道病治疗女性阴道微生物组和生殖道细胞因子的时间变化。
Front Immunol. 2021 Sep 14;12:730986. doi: 10.3389/fimmu.2021.730986. eCollection 2021.
4
A Review of Evidence-Based Care of Symptomatic Trichomoniasis and Asymptomatic Trichomonas vaginalis Infections.有症状滴虫病和无症状阴道毛滴虫感染的循证护理综述
Clin Infect Dis. 2015 Dec 15;61 Suppl 8(Suppl 8):S837-48. doi: 10.1093/cid/civ738.
5
Changes in the contribution of genital tract infections to HIV acquisition among Kenyan high-risk women from 1993 to 2012.1993年至2012年肯尼亚高危女性中生殖道感染对感染艾滋病毒影响的变化。
AIDS. 2015 Jun 1;29(9):1077-85. doi: 10.1097/QAD.0000000000000646.
6
Genital infections and syndromic diagnosis among HIV-infected women in HIV care programmes in Kenya.肯尼亚艾滋病护理项目中感染艾滋病病毒女性的生殖器感染与综合征诊断
Int J STD AIDS. 2016 Jan;27(1):19-24. doi: 10.1177/0956462415568982. Epub 2015 Jan 22.
7
Mixed vaginitis-more than coinfection and with therapeutic implications.混合性阴道炎——不仅仅是混合感染，还具有治疗意义。
Curr Infect Dis Rep. 2013 Apr;15(2):104-8. doi: 10.1007/s11908-013-0325-5.
本文引用的文献
1
Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.替诺福韦凝胶作为一种抗逆转录病毒的杀微生物剂，用于预防女性感染艾滋病毒的有效性和安全性。
Science. 2010 Sep 3;329(5996):1168-74. doi: 10.1126/science.1193748. Epub 2010 Jul 19.
2
Disentangling contributions of reproductive tract infections to HIV acquisition in African Women.解析非洲女性生殖道感染对感染艾滋病毒的影响因素
Sex Transm Dis. 2009 Jun;36(6):357-64. doi: 10.1097/OLQ.0b013e3181a4f695.
3
Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies.细菌性阴道病与HIV感染：已发表研究的荟萃分析
AIDS. 2008 Jul 31;22(12):1493-501. doi: 10.1097/QAD.0b013e3283021a37.
4
Bacterial vaginosis and vaginal yeast, but not vaginal cleansing, increase HIV-1 acquisition in African women.细菌性阴道病和阴道酵母菌感染，而非阴道冲洗，会增加非洲女性感染HIV-1的几率。
J Acquir Immune Defic Syndr. 2008 Jun 1;48(2):203-10. doi: 10.1097/QAI.0b013e3181743936.
5
Improvement of vaginal health for Kenyan women at risk for acquisition of human immunodeficiency virus type 1: results of a randomized trial.改善肯尼亚有感染1型人类免疫缺陷病毒风险的女性的阴道健康：一项随机试验的结果。
J Infect Dis. 2008 May 15;197(10):1361-8. doi: 10.1086/587490.
6
Trichomonas vaginalis infection and human immunodeficiency virus acquisition in African women.非洲女性阴道毛滴虫感染与人类免疫缺陷病毒感染情况
J Infect Dis. 2008 Feb 15;197(4):548-54. doi: 10.1086/526496.
7
A randomized trial of metronidazole in asymptomatic bacterial vaginosis to prevent the acquisition of sexually transmitted diseases.一项关于甲硝唑用于无症状细菌性阴道病以预防性传播疾病的随机试验。
Am J Obstet Gynecol. 2007 Jun;196(6):517.e1-6. doi: 10.1016/j.ajog.2007.02.048.
8
Infection with Trichomonas vaginalis increases the risk of HIV-1 acquisition.感染阴道毛滴虫会增加感染HIV-1的风险。
J Infect Dis. 2007 Mar 1;195(5):698-702. doi: 10.1086/511278. Epub 2007 Jan 22.
9
High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence.口服甲硝唑治疗后12个月内细菌性阴道病的高复发率及复发相关因素。
J Infect Dis. 2006 Jun 1;193(11):1478-86. doi: 10.1086/503780. Epub 2006 Apr 26.
10
Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis.使用0.75%甲硝唑阴道凝胶进行抑制性抗菌治疗以预防复发性细菌性阴道病。
Am J Obstet Gynecol. 2006 May;194(5):1283-9. doi: 10.1016/j.ajog.2005.11.041. Epub 2006 Apr 21.
Zotero 插件