Echevarría J M, Téllez A, Martínez-Martín P
Centro Nacional de Microbiología, Virología e Inmunología Sanitarias, Madrid, Spain.
J Infect Dis. 1990 Sep;162(3):621-6. doi: 10.1093/infdis/162.3.621.
The subclass distribution of the varicella-zoster virus (VZV)-specific IgG antibody response was studied in serum samples from 22 patients with primary varicella and 34 with recurrent VZV infections and in cerebrospinal fluid (CSF) samples from 22 patients with recurrent infection who presented with symptoms of aseptic meningitis. IgG1 and 3 were the dominant subclasses among patients with primary and recurrent infections; IgG1 was also prevalent in the CSF samples. The VZV IgG subclass distribution patterns did not allow differentiation between primary and recurrent infections. However, seroconversions for IgG2, 3, or 4 were observed among patients with recurrences who were negative for specific IgM, suggesting that qualitative tests for serum IgG subclass antibody could be helpful for diagnosis in such cases. Herpes simplex virus-specific IgG was found in CSF samples from several patients with meningitis. The results suggest that calculation of the antibody to albumin index is better than IgG subclass antibody assays for discriminating the causative agent in these cases.
研究了22例原发性水痘患者和34例复发性水痘-带状疱疹病毒（VZV）感染患者血清样本以及22例出现无菌性脑膜炎症状的复发性感染患者脑脊液（CSF）样本中VZV特异性IgG抗体反应的亚类分布。IgG1和IgG3是原发性和复发性感染患者中的主要亚类；IgG1在脑脊液样本中也很普遍。VZV IgG亚类分布模式无法区分原发性和复发性感染。然而，在特异性IgM阴性的复发患者中观察到了IgG2、IgG3或IgG4的血清转化，这表明血清IgG亚类抗体的定性检测可能有助于此类病例的诊断。在几例脑膜炎患者的脑脊液样本中发现了单纯疱疹病毒特异性IgG。结果表明，在这些病例中，计算抗体与白蛋白指数比IgG亚类抗体检测更有助于鉴别病原体。
