Martínez-Martín P, García-Sáiz A, Rapún J L, Echevarría J M
J Med Virol. 1985 Jun;16(2):201-9. doi: 10.1002/jmv.1890160213.
IgG antibodies to varicella-zoster virus (VZV) were detected by indirect enzyme-immunoassay (EIA) in CSF of two patients with acute aseptic meningitis syndrome (AAMS) not associated with evident cutaneous lesion or recent history of zoster infection. Their characteristic features and serological data are compared with those observed in two patients with AAMS and zoster cutaneous lesions, and in 13 patients with AAMS of unknown or other etiology. According to several indexes applied to assess the origin of the detected antibodies, it is concluded that VZV IgG antibodies are of intrathecal production. The possible etiologic relationship between the neurological syndrome and the detection of VZV antibodies in CSF is discussed. Routine serological procedures are proposed for the diagnosis of CNS acute infections of probable viral etiology that should provide additional data on these rarely described cases.
通过间接酶免疫测定法（EIA）在两名患有急性无菌性脑膜炎综合征（AAMS）的患者脑脊液中检测到水痘-带状疱疹病毒（VZV）的IgG抗体，这两名患者无明显皮肤损害或近期带状疱疹感染史。将他们的特征和血清学数据与两名患有AAMS且有带状疱疹皮肤损害的患者以及13名病因不明或由其他病因引起AAMS的患者的数据进行了比较。根据用于评估检测到的抗体来源的几个指标，得出VZV IgG抗体是鞘内产生的结论。讨论了神经综合征与脑脊液中检测到VZV抗体之间可能的病因关系。建议采用常规血清学方法诊断可能由病毒引起的中枢神经系统急性感染，这应为这些罕见病例提供更多数据。
