Sculley T B, Apolloni A, Hurren L, Moss D J, Cooper D A
Queensland Institute of Medical Research, Brisbane.
J Infect Dis. 1990 Sep;162(3):643-8. doi: 10.1093/infdis/162.3.642.
A possible cofactor in human immunodeficiency virus (HIV) infection is the Epstein-Barr virus (EBV), which is divided into two primary types that differ significantly in their transformation efficiency. The B-type EBV cell line is much more difficult to establish than the A-type. The extent of systemic B-type EBV infection was assessed in HIV-positive subjects and controls. Lymphoblastoid cell lines were established from 26 HIV-positive subjects and analyzed for the presence of A- or B-type EBV by Southern analysis and immunoblotting. Some 19% of HIV-positive persons were infected with B-type EBV, 69% with A-type, and 12% with both types. Analysis of the individual strains of EBV harbored by the HIV-positive subjects showed that HIV-induced immunosuppression had not led to increased susceptibility to repeated EBV infections. However, the occurrence of B-type infection in HIV-positive subjects was sixfold higher than that in the general community, indicating that HIV-induced immunodeficiency or HIV itself specifically enhanced the expression of the B-type EBV.
人类免疫缺陷病毒（HIV）感染的一个可能辅助因子是爱泼斯坦-巴尔病毒（EBV），它分为两种主要类型，其转化效率差异显著。B型EBV细胞系比A型更难建立。在HIV阳性受试者和对照组中评估了全身性B型EBV感染的程度。从26名HIV阳性受试者中建立了淋巴母细胞系，并通过Southern分析和免疫印迹分析A或B型EBV的存在情况。约19%的HIV阳性者感染了B型EBV，69%感染了A型，12%同时感染了两种类型。对HIV阳性受试者携带的EBV个体菌株的分析表明，HIV诱导的免疫抑制并未导致对反复EBV感染的易感性增加。然而，HIV阳性受试者中B型感染的发生率比普通人群高六倍，这表明HIV诱导的免疫缺陷或HIV本身特异性地增强了B型EBV的表达。
