Prayitno Adi
Department of Pathology Anatomic, Faculty of Medicine, University of Sebelas Maret, Surakarta, Indonesia.
J Carcinog. 2006 May 10;5:13. doi: 10.1186/1477-3163-5-13.
The Early-7 (E7) protein of HPV binds to the underphosphorelated form of the tumor suppressor protein--pRb and displaces the E2F transcription factor that is normally bound by pRb. The latent membrane protein-1 (LMP-1) of EBV prevents apoptosis of B cells by up regulating the expression of bcl-2, and it activates growth promoting pathway that are normally triggered by T cell-derivate signal. The aims of this study to know that in cervical cancer stay HPV and EBV. DNA was isolated from nineteen sample cervical cancer tissues frozen section. Diagnose related with HPV and EBV was made by Polymerase Chains Reaction (PCR). The result of this experiment showed that from 19 samples diagnosed as cervical cancer, 17 samples are positive HPV and 13 samples had HPV and EBV positive. The conclusion of this experiment is 89% of cervical cancers are infected with HPV and 68% also infected with HPV and EBV.
人乳头瘤病毒（HPV）的早期蛋白7（E7）与肿瘤抑制蛋白——低磷酸化形式的视网膜母细胞瘤蛋白（pRb）结合，并取代通常与pRb结合的E2F转录因子。EB病毒的潜伏膜蛋白1（LMP-1）通过上调bcl-2的表达来阻止B细胞凋亡，并且它激活通常由T细胞衍生信号触发的促生长途径。本研究的目的是了解宫颈癌中HPV和EBV的存在情况。从19份宫颈癌组织冰冻切片样本中提取DNA。通过聚合酶链反应（PCR）对HPV和EBV进行诊断。该实验结果显示，在诊断为宫颈癌的19份样本中，17份HPV呈阳性，13份HPV和EBV均呈阳性。该实验的结论是，89%的宫颈癌感染了HPV，68%同时感染了HPV和EBV。
