Rao R K, Ramakrishnan C V
Department of Biochemistry, Faculty of Science, M.S. University of Baroda, India.
J Pediatr Gastroenterol Nutr. 1990 Jul;11(1):96-100. doi: 10.1097/00005176-199007000-00019.
Postweaning protein malnutrition imposed on normally weaned or neonatally undernourished rats fed a low-protein diet induced retardation of body and small intestinal growth. A sparing effect on intestinal growth as compared to body growth was observed during protein malnutrition. Postweaning protein malnutrition in normally weaned rats resulted in a significant elevation of specific activities of inositol triphosphatase and phytase in duodenum and jejunum without affecting the activity in ileum. On the other hand, protein malnutrition imposed on neonatally undernourished rats resulted in a significant decrease of enzyme activities in small intestinal segments. These results suggest altered activity of intestinal inositol phosphatase in postweaning protein malnutrition with the direction of effects dependent on the neonatal nutritional status.
给正常断奶或新生期营养不良且喂食低蛋白饮食的大鼠断奶后施加蛋白质营养不良，会导致身体和小肠生长迟缓。在蛋白质营养不良期间，观察到对肠道生长比对身体生长有更明显的生长抑制作用。正常断奶大鼠断奶后蛋白质营养不良导致十二指肠和空肠中肌醇三磷酸酶和植酸酶的比活性显著升高，而回肠中的活性不受影响。另一方面，给新生期营养不良的大鼠施加蛋白质营养不良会导致小肠各段酶活性显著降低。这些结果表明，断奶后蛋白质营养不良时肠道肌醇磷酸酶的活性发生了改变，其影响方向取决于新生期的营养状况。
