Department of Chemistry, Chittagong University of Engineering and Technology, Chittagong, Bangladesh.
Planta Med. 2011 Nov;77(16):1848-51. doi: 10.1055/s-0030-1271178. Epub 2011 Jun 14.
One new drimane-type sesquiterpenoid, 3 β-angeloyloxy-7-epifutronolide (1), and one new natural product, polygonumate (2), along with six known drimane-type sesquiterpenes [dendocarbin L (3), (+) winterin (4), (+) fuegin (5), changweikangic acid A (6), futronolide (7), and 7-ketoisodrimenin (8)] were isolated from the whole plant of Polygonum hydropiper Linn. Their structures were determined using spectroscopic techniques. Single-crystal X-ray diffraction study on dendocarbin L (3) and ¹³C-NMR spectroscopic data of (+) winterin (4) are described for the first time. Compound 6 was evaluated for inhibitions of α-chymotrypsin, acetylcholinesterase, and butyrylcholinesterase enzymes.
从水麻整个植株中分离得到一个新的裂环烯醚萜类倍半萜 3β-当归酰氧基-7-表佛桐内酯（1）和一个新的天然产物 （2），以及六个已知的裂环烯醚萜类倍半萜[（+）冬凌草甲素（3）、（+）冬凌草乙素（4）、（+）佛桐内酯（5）、changweikangic 酸 A（6）、佛桐内酯（7）和 7-酮异土木香内酯（8）]。采用光谱技术确定了它们的结构。首次对 dendocarbin L（3）进行了单晶 X 射线衍射研究，并对（+）冬凌草乙素（4）的 ¹³C-NMR 光谱数据进行了描述。对 6 号化合物进行了α-糜蛋白酶、乙酰胆碱酯酶和丁酰胆碱酯酶抑制活性评价。
