Liu Ming-Sheng, Liu Chang, Zhang Xiao-po, Sheng Lin, Zhang Jun-qing, Kang Sheng-li
School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571101, PR China.
Chem Pharm Bull (Tokyo). 2010 Sep;58(9):1224-6. doi: 10.1248/cpb.58.1224.
Two new drimane sesquiterpenoids, changweikangic acid A (1) and B (2), were isolated from Compound Changweikang. Their structures were established on basis of extensive spectroscopic analyses including two dimensional (2D) NMR and X-ray crystallographic data. The two compounds were evaluated for their inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophage cell line, RAW 264.7 cells.
从复方肠胃康中分离得到两种新的菖蒲烷倍半萜类化合物，肠胃康酸A（1）和B（2）。基于包括二维（2D）核磁共振和X射线晶体学数据在内的广泛光谱分析确定了它们的结构。评估了这两种化合物对脂多糖激活的巨噬细胞系RAW 264.7细胞中一氧化氮产生的抑制活性。
