从复方肠胃康中分离得到的两种新的菖蒲烷倍半萜及其对一氧化氮生成的抑制活性

Two new drimane sesquiterpenoids from compound Changweikang and their inhibitory activity against nitric oxide production.

作者信息

Liu Ming-Sheng, Liu Chang, Zhang Xiao-po, Sheng Lin, Zhang Jun-qing, Kang Sheng-li

机构信息

School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571101, PR China.

出版信息

Chem Pharm Bull (Tokyo). 2010 Sep;58(9):1224-6. doi: 10.1248/cpb.58.1224.

DOI:10.1248/cpb.58.1224

PMID:20823604

Abstract

Two new drimane sesquiterpenoids, changweikangic acid A (1) and B (2), were isolated from Compound Changweikang. Their structures were established on basis of extensive spectroscopic analyses including two dimensional (2D) NMR and X-ray crystallographic data. The two compounds were evaluated for their inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophage cell line, RAW 264.7 cells.

摘要

从复方肠胃康中分离得到两种新的菖蒲烷倍半萜类化合物，肠胃康酸A（1）和B（2）。基于包括二维（2D）核磁共振和X射线晶体学数据在内的广泛光谱分析确定了它们的结构。评估了这两种化合物对脂多糖激活的巨噬细胞系RAW 264.7细胞中一氧化氮产生的抑制活性。