Centre for Drug and Herbal Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
Pharmacotherapeutics Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia.
Evid Based Complement Alternat Med. 2014;2014:782830. doi: 10.1155/2014/782830. Epub 2014 Apr 16.
Persicaria hydropiper (L.) Delarbre, belonging to Polygonaceae family, is a common weed found in most of the temperate countries including Bangladesh, China, Malaysia, and Japan. The plant is also referred to as "marsh pepper" or "smart weed." It appears to be a useful herb with evidence-based medicinal properties. The present work addresses the botanical description, traditional uses, phytochemistry, pharmacology, and toxicology of P. hydropiper. All plant parts have been commonly used in the traditional systems of medicines. Flavonoids are the major group of phytochemical components followed by drimane-type sesquiterpenes and sesquiterpenoids, as well as phenylpropanoids. Different extracts and plant parts showed remarkable pharmacological activities including antioxidant, antibacterial, antifungal, antihelminth, antifeedant, cytotoxicity, anti-inflammatory, antinociceptive, oestrogenicity, antifertility, antiadipogenicity, and neuroprotection. Mutagenicity and acute and subchronic toxicities of the plant were also reported. P. hydropiper has tremendous medicinal properties that could further be investigated for the development of evidence-based herbal products.
水蓼（Polygonaceae 科）是一种常见的杂草，分布于包括孟加拉国、中国、马来西亚和日本在内的大多数温带国家。该植物也被称为“沼泽胡椒”或“聪明草”。它似乎是一种具有基于证据的药用特性的有用草药。本工作介绍了水蓼的植物学描述、传统用途、植物化学、药理学和毒理学。所有植物部分在传统药物体系中都得到了广泛应用。类黄酮是主要的植物化学成分，其次是二萜型倍半萜和倍半萜类，以及苯丙素类。不同的提取物和植物部分表现出显著的药理活性，包括抗氧化、抗菌、抗真菌、抗寄生虫、拒食、细胞毒性、抗炎、镇痛、雌激素、抗生育、抗脂肪生成和神经保护。该植物的致突变性以及急性和亚慢性毒性也有报道。水蓼具有巨大的药用价值，可以进一步研究开发基于证据的草药产品。
