MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Macromol Rapid Commun. 2011 Jul 15;32(14):1077-81. doi: 10.1002/marc.201100196. Epub 2011 Jun 14.
A novel comb-like derivative CPEG-g-DNQ was prepared by incorporating light responsive 2-diazo-1,2-naphthoquinone (DNQ) groups into the structure of comb-like poly(ethylene glycol) (CPEG). DLS and TEM results showed that CPEG-g-DNQ self-assembled into spherical micelles with an average size of about 135 nm in water. Upon exposure to light, the micelles could be disrupted because of the conversion of hydrophobic DNQ to hydrophilic 3-indenecarboylic acid. Additionally, hydrophobic coumarin 102 was successfully loaded into the micelles and photo-induced ON-OFF release was demonstrated by fluorescence spectroscopy. MTT assay revealed that the micelles are biocompatible. These photo-responsive micelles might have great potential for controlled release of hydrophobic drugs.
一种新型梳状衍生物 CPEG-g-DNQ 通过将光响应 2-重氮-1,2-萘醌 (DNQ) 基团引入梳状聚乙二醇 (CPEG) 的结构中制备得到。DLS 和 TEM 结果表明，CPEG-g-DNQ 在水中自组装成平均粒径约为 135nm 的球形胶束。在光照下，由于疏水性 DNQ 转化为亲水性 3-茚满羧酸，胶束可能会被破坏。此外，成功将疏水性香豆素 102 载入胶束中，并通过荧光光谱证明了光诱导的开-关释放。MTT 试验表明，胶束具有良好的生物相容性。这些光响应性胶束可能在控制释放疏水性药物方面具有巨大的潜力。
