从野菰中分离具有多药耐药 (MDR) 逆转性质的新型酚类化合物。
Isolation of novel phenolic compounds with multidrug resistance (MDR) reversal properties from Onychium japonicum.
机构信息
School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, P. R. China.
出版信息
Chem Biodivers. 2011 Jun;8(6):1112-20. doi: 10.1002/cbdv.201000224.
We isolated seven novel compounds, namely, 3',4',6-trihydroxy-2,4-dimethoxy-3-(3″,4″-dihydroxybenzyl)chalcone (1), 3',6-dihydroxy-2,4,4'-trimethoxy-3-(3″,4″-dihydroxybenzyl)chalcone (2), α,β-dihydro-3',6-dihydroxy-2,4,6'-trimethoxy-3-(3″,4″-dihydroxybenzyl)chalcone (3), 3',4,4'-trihydroxy-2,6-dimethoxychalcone (4), 4',5,7-trihydroxy-6-(3″,4″-dihydroxybenzyl)flavone (5), 3-(3',4'-dihydroxybenzyl)-6,7-dihydroxycoumarin (6), 3-(3',4'-dihydroxyphenyl)-3,4-dihydroisocoumarin (7), as well as a known compound, 3',4',7-trihydroxy-5-methoxyflavanone (8) from the whole grass of Onychium japonicum, and elucidated their structures by spectroscopic methods. Compounds 1-3 exhibited significant multidrug resistance (MDR) reversal effects on MCF-7/ADR and Bel-7402/5-Fu cell lines.
我们从淡竹叶全草中分离得到了 7 个新化合物，分别为：3',4',6-三羟基-2,4-二甲氧基-3-(3",4"-二羟基苄基)查耳酮（1）、3',6-二羟基-2,4,4'-三甲氧基-3-(3",4"-二羟基苄基)查耳酮（2）、α,β-二氢-3',6-二羟基-2,4,6'-三甲氧基-3-(3",4"-二羟基苄基)查耳酮（3）、3',4,4'-三羟基-2,6-二甲氧基查耳酮（4）、4',5,7-三羟基-6-(3",4"-二羟基苄基)黄酮（5）、3-(3',4'-二羟基苄基)-6,7-二羟基香豆素（6）、3-(3',4'-二羟基苯基)-3,4-二氢异香豆素（7），以及一个已知化合物 3',4',7-三羟基-5-甲氧基黄烷酮（8）。我们通过光谱方法阐明了它们的结构。化合物 1-3 对 MCF-7/ADR 和 Bel-7402/5-Fu 细胞系表现出显著的多药耐药（MDR）逆转作用。
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