Zhao Jielu, Fan Xiao, Wang Sujuan, Li Shuai, Shang Suqin, Yang Yongchun, Xu Nianjun, Lü Yang, Shi Jiangong
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing 100050.
J Nat Prod. 2004 Jun;67(6):1032-5. doi: 10.1021/np030546+.
Eight new bromophenol derivatives, 2,3-dibromo-4,5-dihydroxybenzyl methyl sulfoxide (1), 4-(2,3-dibromo-4,5-dihydroxyphenyl)-3-butene-2-one (2), 2-(3-bromo-5-hydroxy-4-methoxyphenyl)-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid (3), 2-(3-bromo-5-hydroxy-4-methoxyphenyl)-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid methyl ester (4), 2-phenyl-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid (5), 4'-methoxy-2'',3',3''-tribromo-4'',5',5''-trihydroxydiphenylacetic acid (6), and 3-bromo-5-hydroxy-4-methoxyphenylacetic acid (7) and its methyl ester (8), together with a known bromophenol, 3-bromo-5-hydroxy-4-methoxybenzoic acid (9), were isolated from the red alga Rhodomela confervoides. Their structures were elucidated by spectroscopic methods including IR, EIMS, FABMS, ESIMS, HRFABMS, HRESIMS, 1D and 2D NMR, and single-crystal X-ray structure analysis. Compounds 1-4, 8, and 9 were found inactive against several human cancer cell lines and microorganisms.
从红藻密毛红皮藻（Rhodomela confervoides）中分离出8种新的溴酚衍生物，即2,3-二溴-4,5-二羟基苄基甲基亚砜（1）、4-(2,3-二溴-4,5-二羟基苯基)-3-丁烯-2-酮（2）、2-(3-溴-5-羟基-4-甲氧基苯基)-3-(2,3-二溴-4,5-二羟基苯基)丙酸（3）、2-(3-溴-5-羟基-4-甲氧基苯基)-3-(2,3-二溴-4,5-二羟基苯基)丙酸甲酯（4）、2-苯基-3-(2,3-二溴-4,5-二羟基苯基)丙酸（5）、4'-甲氧基-2'',3',3''-三溴-4'',5',5''-三羟基二苯乙酸（6）、3-溴-5-羟基-4-甲氧基苯乙酸（7）及其甲酯（8），以及一种已知的溴酚3-溴-5-羟基-4-甲氧基苯甲酸（9）。通过红外光谱（IR）、电子轰击质谱（EIMS）、快原子轰击质谱（FABMS）、电喷雾电离质谱（ESIMS）、高分辨快原子轰击质谱（HRFABMS）、高分辨电喷雾电离质谱（HRESIMS）、一维和二维核磁共振（1D和2D NMR）以及单晶X射线结构分析等光谱方法对它们的结构进行了阐明。发现化合物1 -
