Gogin E E
Ter Arkh. 2011;83(4):5-13.
Fundamental investigations of the role of the endothelium and cell periphery in regulation of vascular tonicity in the last decade of the XX century brought a radical revision of the former conception of circulation. It was discovered that distribution of blood in the arteries depends on operational requirements of the tissues and organs, it is not determined by integrating mechanisms of neuroendocrine regulation. Problems of hemodynamics and microcirculation give rise to much discussion now because neurogenic hypophysis of cardiovascular disease development still has many supporters among medical profession. Progressive disturbances of circulation and hemodynamics may be produced by diseases known as nosological entities for many years. Arterial hypertension often plays a leading role in common polymorbid combinations. It is important to include in basic treatment additional modalities taking consideration of existing at the moment leading risk factors. This involves an individual approach to choice of therapy.
20世纪最后十年对内皮和细胞外周在血管张力调节中作用的基础研究，使人们对以往的循环概念进行了彻底修正。人们发现，动脉中的血液分布取决于组织和器官的运作需求，而非神经内分泌调节的整合机制所决定。血流动力学和微循环问题如今引发了诸多讨论，因为心血管疾病发展中的神经源性垂体病因在医学界仍有不少支持者。多年来被视为疾病实体的疾病可能会导致循环和血流动力学的渐进性紊乱。动脉高血压在常见的多病症组合中往往起主导作用。在基础治疗中纳入考虑当前主要危险因素的额外治疗方法很重要。这涉及到治疗选择的个体化方法。
