[Comparative effectiveness of mianserin and pyrazidol in endogenous depression].

Psychotropic activity of miansan (mianserin, lerivon) and pyrazidol was subjected to a comparative clinico-statistical study in depressions within the framework of phasically going endogenous psychoses. There were 2 clinically comparable groups each made up of 21 patients. Complete and appreciable efficacy was revealed in 16 patients (76.8%) receiving miansan and in 14 patients (67.2%) on pyrazidol. The general antidepressant effect of miansan correlated statistically significantly with sedative (anxiolytic and hypnotic) effect of the drug. As far as pyrazidol is concerned, the intensity of sedative and stimulating components of the antidepressant action did not essentially differ. No marked side effects were recorded even on drug administration in high doses, including persons with the signs of inferiority. The data obtained attest to the fact that miansan should be preferably used in anxious, anesthetic depressions and depressive paranoid conditions including those resistant to the preceding therapy with tricyclic antidepressants.