Rapisarda V, Bongiorno G
Adv Biochem Psychopharmacol. 1982;32:141-9.
The Authors report a double-blind study to compare mianserin and chlorimipramine efficacy in the treatment of two groups of 30 depressed patients. The trial confirms that mianserin has an antidepressant effect similar to that of chlorimipramine with fewer side effects. During the study some subjects were tested by Electrodermic Response to acoustic stimuli, comparing the results with the responses of patients treated with chlorimipramine. Furthermore, the plasmatic beta-endorphin level in 10 subjects treated with mianserin was compared with values found in basic conditions. The significant decrease of the plasmatic beta-endorphin level after treatment with mianserin suggests that the drug may act as an antidepressant, by varying the endorphinergic cerebral activity.
作者报告了一项双盲研究，比较米安色林和氯米帕明对两组各30名抑郁症患者的治疗效果。该试验证实，米安色林具有与氯米帕明相似的抗抑郁作用，且副作用较少。在研究过程中，对一些受试者进行了听觉刺激的皮肤电反应测试，并将结果与接受氯米帕明治疗的患者的反应进行比较。此外，还将10名接受米安色林治疗的受试者的血浆β-内啡肽水平与基础状态下的值进行了比较。米安色林治疗后血浆β-内啡肽水平的显著下降表明，该药物可能通过改变内源性阿片肽能脑活动而发挥抗抑郁作用。
