(-)-8-表愈创木素的简洁全合成。
Concise total synthesis of (-)-8-epigrosheimin.
机构信息
State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
出版信息
Org Lett. 2011 Jul 15;13(14):3670-3. doi: 10.1021/ol201322w. Epub 2011 Jun 15.
PMID:21675754
Abstract
A highly efficient route was developed to synthesize (-)-8-epigrosheimin in four steps from aldehyde 2 based on a substrate-controlled method. The key steps of the synthesis included (1) a stereo- and regioselective allylation addition, (2) an intramolecular translactonization, and (3) an aldehyde-ene cyclization.
摘要
开发了一条从醛 2 出发，经四步反应以底物控制方法高效合成(-)-8-表格罗舍米林的路线。合成的关键步骤包括：(1)立体和区域选择性的烯丙基加成反应，(2)分子内的转内酯化反应，以及(3)醛-烯环化反应。
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