Department of Psychiatry, Amager Hospital, Capital Region of Denmark, Copenhagen University Hospital, Copenhagen, Denmark.
Alcohol Clin Exp Res. 2011 Jul;35(7):1315-20. doi: 10.1111/j.1530-0277.2011.01467.x. Epub 2011 Apr 19.
Few population-based studies have investigated associations between parental history of alcoholism and the risk of alcoholism in offspring. The aim was to investigate in a large cohort the risk of alcohol use disorders (AUD) in the offspring of parents with or without AUD and with or without hospitalization for other psychiatric disorder (OPD).
Longitudinal birth cohort study included 7,177 men and women born in Copenhagen between October 1959 and December 1961. Cases of AUD were identified in 3 Danish health registers and cases of OPD in the Danish Psychiatric Central Register. Offspring registration with AUD was analyzed in relation to parental registration with AUD and OPD. Covariates were offspring gender and parental social status.
Both maternal and paternal registration with AUD significantly predicted offspring risk of AUD (odds ratios 1.96; 95% CI 1.42 to 2.71 and 1.99; 95% CI 1.54 to 2.68, respectively). The association between maternal, but not paternal, OPD and offspring AUD was also significant (odds ratios 1.46; 95% CI 1.15 to 1.86 and 1.26; 95% CI 0.95 to 1.66, respectively). Other predictors were male gender and parental social status. A significant interaction was observed between paternal AUD and offspring gender on offspring AUD, and stratified analyses showed particularly strong associations of both paternal and maternal AUD with offspring AUD in female cohort members.
Parental AUD was associated with an increased risk of offspring AUD independent of other significant predictors, such as gender, parental social status, and parental psychiatric hospitalization with other diagnoses. Furthermore, this association appeared to be stronger among female than male offspring. The results suggest that inherited factors related to alcoholism are at least as important in determining the risk of alcoholism among daughters as among sons.
很少有基于人群的研究调查父母酗酒史与子女酗酒风险之间的关系。本研究旨在通过一项大型队列研究，调查父母有或无酗酒史、有或无其他精神障碍住院史（OPD）的子女发生酒精使用障碍（AUD）的风险。
这是一项纵向出生队列研究，纳入了 1959 年 10 月至 1961 年 12 月间在哥本哈根出生的 7177 名男性和女性。丹麦的 3 个健康登记处确定了 AUD 病例，丹麦精神病中央登记处确定了 OPD 病例。分析了子女 AUD 登记与父母 AUD 和 OPD 登记的关系。协变量为子女性别和父母社会地位。
母亲和父亲的 AUD 登记均显著预测了子女患 AUD 的风险（比值比 1.96；95%置信区间 1.42 至 2.71 和 1.99；95%置信区间 1.54 至 2.68）。母亲的 OPD 与子女 AUD 之间存在显著关联，但父亲的 OPD 与子女 AUD 之间没有显著关联（比值比 1.46；95%置信区间 1.15 至 1.86 和 1.26；95%置信区间 0.95 至 1.66）。其他预测因素为子女的性别和父母的社会地位。在子女 AUD 方面，观察到父亲 AUD 与子女性别之间存在显著的交互作用，分层分析显示，在女性队列成员中，父亲和母亲的 AUD 与子女 AUD 之间的关联尤其强烈。
父母 AUD 与子女 AUD 风险增加相关，与其他重要预测因素无关，如性别、父母社会地位和父母其他诊断的精神病住院。此外，这种关联在女性子女中似乎比男性子女更强。研究结果表明，与酗酒相关的遗传因素在确定女儿和儿子患酒精中毒的风险方面至少同样重要。
