双相障碍相关事件相关γ振荡的遗传和环境影响。
The genetic and environmental influences of event-related gamma oscillations on bipolar disorder.
机构信息
Psychology Research Laboratory, Harvard Medical School, McLean Hospital Research Service, Boston, MA, USA.
出版信息
Bipolar Disord. 2011 May;13(3):260-71. doi: 10.1111/j.1399-5618.2011.00925.x.
OBJECTIVES
Gamma oscillations have been proposed to play an important role in neural information coding. There have been a limited number of electrophysiology studies in evoked gamma band responses (GBRs) in bipolar disorder (BPD). It is also unclear whether GBR deficits, if present, are potential endophenotypes for BPD as little is known about the heritability of GBRs. The present study aimed to examine whether GBRs derived from two auditory tasks, the oddball task and the dual-click paradigm, are potential BPD endophenotypes.
METHODS
A total of 308 subjects were included in this study: 198 healthy controls, 59 BPD patients (22 monozygotic BPD twins and 37 BPD patients from 31 families), and 51 unaffected relatives. The evoked gamma responses were calculated using a Morlet wavelet transformation. Structural equation modelling was applied to obtain the genetic (heritability) and environment estimates in each GBR variable and their (genetic) overlap with BPD.
RESULTS
The heritability estimates of GBR to standard stimuli were 0.51 and 0.35 to target stimuli in the oddball task. However, neither response type was impaired in BPD patients or their unaffected relatives. The heritability estimates of GBR to S1 stimuli were 0.54 and 0.50 to S2 stimuli in the dual-click paradigm. BPD patients had reduced gamma power and suppression to S1 stimuli but their unaffected relatives did not.
CONCLUSIONS
Evoked GBRs are heritable traits. However, GBR deficits are not observed in clinically unaffected relatives nor associated with BPD. Gamma responses do not appear to satisfy criteria for being BPD endophenotypes.
目的
伽马振荡被认为在神经信息编码中起着重要作用。在双相障碍（BPD）的双相诱发电位伽马带反应（GBRs）的电生理学研究数量有限。目前尚不清楚GBR 缺陷是否是 BPD 的潜在表型，因为对 GBR 的遗传性知之甚少。本研究旨在探讨源自两种听觉任务（Oddball 任务和双点击范式）的 GBR 是否是 BPD 的潜在表型。
方法
本研究共纳入 308 名受试者：198 名健康对照者、59 名 BPD 患者（22 对同卵双胞胎 BPD 患者和 37 名来自 31 个家庭的 BPD 患者）和 51 名未受影响的亲属。使用 Morlet 小波变换计算诱发电位伽马反应。结构方程模型用于获得每个 GBR 变量的遗传（遗传性）和环境估计值及其与 BPD 的（遗传）重叠。
结果
Oddball 任务中标准刺激的 GBR 遗传度估计值分别为 0.51 和 0.35，而目标刺激分别为 0.51 和 0.35。然而，BPD 患者或其未受影响的亲属均未出现反应类型受损的情况。双点击范式中 S1 刺激的 GBR 遗传度估计值分别为 0.54 和 0.50，S2 刺激的 GBR 遗传度估计值分别为 0.54 和 0.50。BPD 患者的 S1 刺激的伽马功率和抑制降低，但他们未受影响的亲属没有。
结论
诱发电位 GBR 是可遗传的特征。然而，在临床未受影响的亲属中未观察到 GBR 缺陷，也与 BPD 无关。伽马反应似乎不符合 BPD 表型的标准。
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