Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Larue D. Carter Memorial Hospital, Indianapolis, IN, USA.
Bipolar Disord. 2018 Feb;20(1):49-59. doi: 10.1111/bdi.12561. Epub 2017 Oct 11.
Bipolar disorder (BD) is associated with reductions in the P3b event-related potential (ERP) response to target auditory stimuli, which suggests deficits in context updating. Previous studies have typically examined these responses in the temporal domain, which may not capture alterations in specific frequencies of phase-locked or induced electrophysiological activity. Therefore, the present study examined early and late ERPs in temporal and frequency domains in a bipolar sample with and without current psychotic features.
The electroencephalogram (EEG) was recorded during an auditory oddball task. Seventy-five BD patients and 98 healthy controls (HCs) discriminated between standard and target tones. N1 ERPs to standards and P3b ERPs to targets were analyzed in the temporal domain. Event-related spectral perturbation (ERSP) and inter-trial coherence (ITC) were analyzed in the frequency domain.
The early N1 response to standard tones was not significantly different between the total HC and BD samples irrespective of psychotic features. However, N1 amplitude was reduced in BD patients with psychotic features (BDP) compared to HCs and BD patients without psychotic features. P3b was reduced in BD patients versus HCs, with the BDP sample having the most reduced amplitude. In the time-frequency analysis, delta and theta ERSP and ITC were reduced across the time window for both standard and target stimuli in BD patients compared to HCs, but did not differ in the psychotic features analysis.
The results provide neural evidence that BD is associated with disrupted sensory, attentional, and cognitive processing of auditory stimuli, which may be worsened with the presence of psychotic features.
双相情感障碍（BD）与听觉靶刺激的 P3b 事件相关电位（ERP）反应减少有关，这表明在上下文更新方面存在缺陷。先前的研究通常在时域中检查这些反应，这可能无法捕捉到特定相位锁定或诱导电生理活动频率的变化。因此，本研究在存在和不存在当前精神病特征的双相样本中检查了时域和频域中的早期和晚期 ERP。
在听觉Oddball 任务期间记录脑电图（EEG）。75 名 BD 患者和 98 名健康对照者（HCs）区分标准音和目标音。在时域中分析标准音的 N1 ERP 和目标音的 P3b ERP。在频域中分析事件相关光谱扰动（ERSP）和跨试验相干性（ITC）。
标准音的早期 N1 反应在总 HC 和 BD 样本之间无论是否存在精神病特征均无显着差异。然而，与 HCs 和无精神病特征的 BD 患者相比，有精神病特征的 BD 患者（BDP）的 N1 振幅降低。与 HCs 相比，BD 患者的 P3b 减少，BDP 样本的振幅降低幅度最大。在时频分析中，与 HCs 相比，BD 患者在标准和目标刺激的整个时间窗口中 delta 和 theta ERSP 和 ITC 均降低，但在精神病特征分析中无差异。
这些结果提供了神经学证据，表明 BD 与听觉刺激的感觉、注意力和认知处理受损有关，而精神病特征的存在可能会使这种情况恶化。
