Instituto de Virología Dr JM Vanella, Universidad Nacional de Córdoba, Argentina.
Epidemiol Infect. 2012 Mar;140(3):454-61. doi: 10.1017/S0950268811000823. Epub 2011 May 18.
The contribution of parvovirus B19 (B19V) as a causative agent of febrile exanthema (FE) in Cordoba, Argentina, was analysed by detection of viral DNA, and specific IgM and IgG. Serum from 141 patients with FE who were negative for measles and rubella, collected during 2005-2009, plus serum from 31 healthy individuals, were assayed. B19V was the aetiological agent in 14·9% of all FE cases, and in 39·1% in an epidemic year (2007). B19V DNA was detected in 47·6% of IgM-positive FE patients, 30·2% of IgM-negative/IgG-positive FE patients, and 9·7% of healthy controls, indicating B19V long-term infection in ~10% of immunocompetent individuals. Persistent B19V DNA was significantly more frequent in children than adults and in males than females. All patients with acute B19V infection had rash and fever, 85·7% had adenopathy, and only 14·3% had arthropathy. This is the first follow-up study of markers of infection and immunity for B19V infection in Argentina.
分析了在阿根廷科尔多瓦引起发热出疹（FE）的细小病毒 B19（B19V）作为病因的作用，通过检测病毒 DNA 以及特异性 IgM 和 IgG 进行分析。收集了 2005-2009 年间检测麻疹和风疹阴性的 141 例 FE 患者以及 31 例健康个体的血清。B19V 是所有 FE 病例的病因，在流行年（2007 年）为 39.1%。B19V DNA 在 47.6%的 IgM 阳性 FE 患者、30.2%的 IgM 阴性/IgG 阳性 FE 患者和 9.7%的健康对照中被检测到，这表明约 10%的免疫功能正常个体存在 B19V 长期感染。持续性 B19V DNA 在儿童中比在成人中更常见，在男性中比在女性中更常见。所有急性 B19V 感染患者均有皮疹和发热，85.7%有腺病，仅有 14.3%有关节病。这是在阿根廷对 B19V 感染的感染和免疫标志物进行的首次随访研究。
