IRCCS A.O.U. San Martino-IST DISSAL, Department of Dermatology, Genoa, Italy.
Department of Health Sciences, University of Milano-Bicocca, Monza, Italy.
J Med Virol. 2015 Nov;87(11):1981-4. doi: 10.1002/jmv.24246. Epub 2015 May 12.
Parvovirus B19 (B19V) infection may differently manifest in various age groups. Erythema infectiosum ('fifth disease') is the most common B19V manifestations in children. Arthralgias and arthritis, with or without rash, are common manifestations of B19V infection in adults. Pruritus is usually present in adults and children. However, other cutaneous manifestations and atypical exanthems have been occasionally reported during B19V infection. To investigate the putative role of B19V infection in atypical exanthems, a total of 390 consecutive patients with atypical exanthems were analysed for B19V infection by determining B19V IgG and IgM antibodies titres in acute and convalescent phase as well as B19V DNA detection in serum by polymerase chain reaction (PCR). Atypical exanthems resulted related to B19V infection in 6 of the 120 pediatric (5%) and 14 of the 270 adult patients (5.2%). In conclusion this study reveals that atypical exanthems related to B19V infection are possible both in children and in adults, with a similar prevalence.
细小病毒 B19（B19V）感染在不同年龄组可能有不同的表现。红斑疹（“第五病”）是儿童中最常见的 B19V 表现。关节痛和关节炎，伴有或不伴有皮疹，是成人 B19V 感染的常见表现。瘙痒通常见于成人和儿童。然而，在 B19V 感染期间偶尔也有其他皮肤表现和非典型出疹。为了研究 B19V 感染在非典型出疹中的可能作用，通过在急性和恢复期测定 B19V IgG 和 IgM 抗体滴度以及通过聚合酶链反应（PCR）检测血清中的 B19V DNA，对 390 例连续的非典型出疹患者进行了 B19V 感染分析。在 120 例儿科患者（5%）和 270 例成人患者（5.2%）中，有 6 例和 14 例非典型出疹与 B19V 感染有关。总之，这项研究表明，B19V 感染引起的非典型出疹在儿童和成人中均有可能，且患病率相似。
