Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, People's Republic of China.
Atherosclerosis. 2011 Sep;218(1):147-50. doi: 10.1016/j.atherosclerosis.2011.05.021. Epub 2011 May 27.
The present study was designed to investigate the potential association between the 981C>T polymorphism in protein tyrosine phosphatase 1B (PTP-1B) and coronary artery disease (CAD).
We conducted a hospital-based case-control study with 864 CAD patients and 1008 controls to explore the association between the PTP-1B 981C>T polymorphism and risk of CAD in Chinese Han population.
Subjects with the variant genotypes (CT+TT) had a 52% decreased risk of CAD relative to CC carriers (adjusted odds ratio, 0.48; 95% confidence interval, 0.39-0.60). The 981C>T polymorphism was associated with a higher body mass index and serum triglyceride levels in both CAD patients and controls. Moreover, this polymorphism was found to be associated with a lower serum glucose levels in cases, but not in controls.
Our study demonstrates that the PTP-1B 981C>T polymorphism is associated with decreased risk of CAD in Chinese Han population.
本研究旨在探讨蛋白酪氨酸磷酸酶 1B（PTP-1B）基因 981C>T 多态性与冠状动脉疾病（CAD）之间的潜在关联。
我们进行了一项基于医院的病例对照研究，共纳入 864 例 CAD 患者和 1008 例对照，旨在探讨中国汉族人群中 PTP-1B 981C>T 多态性与 CAD 风险之间的关系。
与 CC 携带者相比，携带变异基因型（CT+TT）的个体患 CAD 的风险降低了 52%（调整后的优势比，0.48；95%置信区间，0.39-0.60）。981C>T 多态性与 CAD 患者和对照者的体重指数和血清甘油三酯水平升高相关。此外，该多态性与病例组的血清葡萄糖水平降低相关，但与对照组无关。
本研究表明，PTP-1B 基因 981C>T 多态性与中国汉族人群 CAD 患病风险降低相关。
